[HTML][HTML] Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
X Chi, X Liu, C Wang, X Zhang, X Li, J Hou… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and
leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide
efficient blockade for viral infection and are a promising category of biological therapies.
Here, using SARS-CoV-2 spike receptor-binding domain (RBD) as a bait, we generate a
panel of humanized single domain antibodies (sdAbs) from a synthetic library. These sdAbs
reveal binding kinetics with the equilibrium dissociation constant (KD) of 0.99–35.5 nM. The …
leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide
efficient blockade for viral infection and are a promising category of biological therapies.
Here, using SARS-CoV-2 spike receptor-binding domain (RBD) as a bait, we generate a
panel of humanized single domain antibodies (sdAbs) from a synthetic library. These sdAbs
reveal binding kinetics with the equilibrium dissociation constant (KD) of 0.99–35.5 nM. The …
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