… hypertensive rats (SHR) between the ages of 18 and 24 mo develop findings suggestive
of heart failure, … SHRs without evidence of heart failure (SHR-NF), and in nonhypertensive …

… hypertension on left ventricular (LV) structure, pump function, and heart failure in Dahl salt-sensitive
rats … yield insights into the pathophysiology of heart failure with normal or preserved …

… gene expression during the transition from stable hypertrophy to heart failure in spontaneously
hypertensive rats with failure (SHR-F) and without failure (SHR-NF). These ratios were …

… evaluated in the isolated ‘working heart’ model. We were able to … heart failure in the
spontaneously hypertensive rat 8 weeks after coronary artery ligation. At this time point, the WKY rat …

… normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) at the ages
of … consistent with heart failure (SHR-F). In comparison to preparations from WKY rats and …

… to heart failure occurs (20,24). During the transition from compensated state to heart failure,
… to apoptosis, may occur during the transition to heart failure (2). Since the morphological …

… rats. This difference may result from several causes, including the following explanation: in
patients with end-stage heart failure… In our animal model showing the transition to heart failure…

… heart failure of our models is different from that of Dahl S rats … heart failure and systolic heart
failure based on hypertension, … ventricular geometry in hypertensive rats which is associated …

… Animal phenotype and characterization of hypertension We first aimed to characterize the
phenotype of the hypertensive rats. There were no differences between groups of animals in …

… rats: 1) aging spontaneously hypertensive rats (SHR) withclinical and pathological evidence
suggesting heart failure (… -matched SHRs with no evidence of heart failure (SHR-NF group), …