[PDF][PDF] iPSC-derived platelets depleted of HLA class-I are inert to anti-HLA class-I and NK cell immunity
D Suzuki - 2020 - repository.kulib.kyoto-u.ac.jp
The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I)
could serve as a universal measure to overcome platelet transfusion refractoriness caused
by HLA-I incompatibility. Here, we developed human induced pluripotent cell-derived HLA-I-
deficient platelets (HLA-KO iPLATs) in a clinically applicable imMKCL system by genetic
manipulation and assessed their immunogenic properties including natural killer (NK) cells,
which reject HLA-I downregulated cells. HLA-KO iPLATs were deficient for all HLA-I but did …
could serve as a universal measure to overcome platelet transfusion refractoriness caused
by HLA-I incompatibility. Here, we developed human induced pluripotent cell-derived HLA-I-
deficient platelets (HLA-KO iPLATs) in a clinically applicable imMKCL system by genetic
manipulation and assessed their immunogenic properties including natural killer (NK) cells,
which reject HLA-I downregulated cells. HLA-KO iPLATs were deficient for all HLA-I but did …
iPSC-derived platelets depleted of HLA class I are inert to anti-HLA class I and natural killer cell immunity
D Suzuki, C Flahou, N Yoshikawa, I Stirblyte… - Stem cell reports, 2020 - cell.com
The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I)
could serve as a universal measure to overcome platelet transfusion refractoriness caused
by HLA-I incompatibility. Here, we developed human induced pluripotent cell-derived HLA-I-
deficient platelets (HLA-KO iPLATs) in a clinically applicable imMKCL system by genetic
manipulation and assessed their immunogenic properties including natural killer (NK) cells,
which reject HLA-I downregulated cells. HLA-KO iPLATs were deficient for all HLA-I but did …
could serve as a universal measure to overcome platelet transfusion refractoriness caused
by HLA-I incompatibility. Here, we developed human induced pluripotent cell-derived HLA-I-
deficient platelets (HLA-KO iPLATs) in a clinically applicable imMKCL system by genetic
manipulation and assessed their immunogenic properties including natural killer (NK) cells,
which reject HLA-I downregulated cells. HLA-KO iPLATs were deficient for all HLA-I but did …
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