Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Y Qiu, T Chen, R Hu, R Zhu, C Li, Y Ruan, X Xie… - Biomarker research, 2021 - Springer
… expressed in M2 to promote tumor growth and progression [14]. Many immunosuppressive
… and immune cells exert immunosuppressive effects partly through promoting M2 polarization

Long non‐coding RNA cox‐2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization

Y Ye, Y Xu, YU Lai, W He, Y Li, R Wang… - Journal of Cellular …, 2018 - Wiley Online Library
Macrophages have been shown to demonstrate a high level of plasticity, … M2 polarized
phenotypes. We investigate long non-coding RNA (lncRNA) cox-2 in macrophage polarization

Macrophage polarity in cancer: a review

M Najafi, N Hashemi Goradel… - Journal of cellular …, 2019 - Wiley Online Library
… Immunosuppression within the TME is a main driver of M2 polarity, so this phenotype can
be shifted back to M1 by targeting immune evasive factors released by cancer and cells within …

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

N Rodrigues Mantuano, MA Stanczak, IA Oliveira… - Cancer immunology …, 2020 - AACR
… showed that M2 polarization in murine macrophages is … hyperglycemia increases M2
macrophage polarization through … showed a reduction in M2 polarization and also abolished the …

… matrix-rosiglitazone complex-mediated immune evasion promotes xenogenic bioengineered root regeneration by altering M1/M2 macrophage polarization

T Lan, J Chen, J Zhang, F Huo, X Han, Z Zhang, Y Xu… - Biomaterials, 2021 - Elsevier
… mechanism of PPAR-γ in escaping immune surveillance to promote bio-roots regeneration
by … facilitate anti-inflammatory M2 macrophage polarization. Our approach demonstrates a …

Macrophage polarization in pathology

A Sica, M Erreni, P Allavena, C Porta - Cellular and molecular life sciences, 2015 - Springer
… pylori induced up-regulation of these enzymes contributes to immune evasion by diverting
the metabolism of l-Arginine toward the production of ornithine and polyamines, rather than …

Lewis lung cancer cells promote SIGNR1 (CD209b)‐mediated macrophages polarization induced by IL‐4 to facilitate immune evasion

X Yan, W Li, L Pan, E Fu, Y Xie… - Journal of Cellular …, 2016 - Wiley Online Library
… mechanism by which DC-SIGN facilitates immune evasion have been poorly described. In
macrophage polarization in the presence of lung cancer cells and to determine the evasion

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

H Yang, Q Zhang, M Xu, L Wang, X Chen, Y Feng, Y Li… - Molecular Cancer, 2020 - Springer
… Consistent with these studies, our data demonstrated that M2 polarization of TAMs was
tightly … a crucial role in TAMs-mediated immune evasion during esophageal carcinogenesis. …

Immune evasion strategies of pathogens in macrophages: the potential for limiting pathogen transmission

Y Ren, FA Khan, NS Pandupuspitasari… - Current issues in …, 2017 - mdpi.com
… As well as bacteria, most monocytotropic viruses may affect macrophage polarization that
in turn leads to the selection between immunosuppression and immunopathology. Human …

Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma

Y Zhang, W Du, Z Chen, C Xiang - Experimental cell research, 2017 - Elsevier
… Moreover, EGFR tyrosine kinase inhibitors could promote antitumor immunity by … demonstrate
a novel immune-promoting function of SPP1 in regulating macrophage polarization. In …