The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… inflammatory responses to the immune system, this so-called a cytokine storm [23]. On the
other hand, severe multi-organ destruction is due to the cytokine storm rather than a direct …

Immune response and cytokine storm in SARS-CoV-2 infection: Risk factors, ways of control and treatment

H Chegni, H Babaii, ZM Hassan… - European Journal of …, 2022 - journals.sagepub.com
… that regulate the activity of the immune system and counteract the cytokine storm. Perhaps
in the future, the drugs used to treat COVID-19 will be Immune system-specific drugs, and the …

VISTA: a target to manage the innate cytokine storm

MA ElTanbouly, Y Zhao, E Schaafsma… - Frontiers in …, 2021 - frontiersin.org
cytokine storms, driven by dysregulated immune responses to viral infections (with a focus
on COVID-19) and autoimmune diseases. Collectively, these findings suggest that the VISTA …

Immune signature of covid-19: In-depth reasons and consequences of the cytokine storm

P Niedźwiedzka-Rystwej, A Majchrzak… - International Journal of …, 2022 - mdpi.com
… the duality of the cytokine storm phenomenon in COVID-19, … that include inflammatory
response and host immunity to … of the immune system that occurs during a cytokine storm. …

Role of PKM2-mediated immunometabolic reprogramming on development of cytokine storm

Z Liu, Y Le, H Chen, J Zhu, D Lu - Frontiers in immunology, 2021 - frontiersin.org
… The cytokine storm is defined as an overreaction of the immune system, which excessively
activates macrophages and lymphocytes, and acutely secretes and releases high levels of …

Cytokine storm and probable role of immunoregulatory drugs in COVID-19: a comprehensive review

A Sadeghzadeh-Bazargan, E Behrangi… - Iranian Journal of …, 2020 - iranjd.ir
… As studies have shown, one of the main causes of death in these patients is lung involvement
resulting from an overactive immune response and the onset of a cytokine cascade. …

The potential role of cytokine storm pathway in the clinical course of viral respiratory pandemic

G Murdaca, F Paladin, A Tonacci, S Isola, A Allegra… - Biomedicines, 2021 - mdpi.com
… The term “cytokine storm” (CS) refers to a spectrum of different immune dysregulation
disorders characterized by constitutional symptoms, systemic inflammation and multiorgan …

Modelling of the innate and adaptive immune response to SARS viral infection, cytokine storm and vaccination

C Leon, A Tokarev, A Bouchnita, V Volpert - Vaccines, 2023 - mdpi.com
… of cytokine storm, we consider proinflammatory cytokines produced by cells of the innate
immune … between inflammation and immune cells, pass to cytokine storm characterized by the …

Cytokine storm in COVID-19 and the treatment simulacrum

A Karimi, SMR Hashemian - Biomedical and Biotechnology …, 2020 - journals.lww.com
… can confirm the theory of cytokine storm. Moreover, the subsequent pulmonary inflammation
due to this aggressive host immune response[ 40 ] cytokine storm is more prevalent when …

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
… and inflammatory indices, such as serum IL-1β, IL-6, IL-10 and d-dimer than those with …
involvement of a cytokine storm [2]. Cytokine storm represents an exaggerated immune response …