Sex differences in immune responses that underlie COVID-19 disease outcomes

T Takahashi, MK Ellingson, P Wong, B Israelow… - Nature, 2020 - nature.com
… Our results revealed key differences in immune responses during the disease course of
SARS-CoV-2 infection in male and female patients. First, we found that the levels of several …

Considering how biological sex impacts immune responses and COVID-19 outcomes

EP Scully, J Haverfield, RL Ursin… - Nature Reviews …, 2020 - nature.com
… , adaptive immune responses or … disease pathogenesis. We discuss how sex differences
in basic molecular and cellular mechanisms can be leveraged to define the immune response

The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy

ABL Fonseca, MV Simon, RA Cazzaniga… - Infectious diseases of …, 2017 - Springer
… This review discusses the innate and adaptive immune responses, and their interactions,
that are known to affect pathogenesis and influence the clinical outcome of leprosy. …

Local immune responses correlate with presentation and outcome in tuberculosis

R Condos, WN Rom, YUKM Liu… - American journal of …, 1998 - atsjournals.org
… of cellular immune response that occurs locally in the lung may affect presentation and
outcome in pulmonary TB, and an understanding of the development of this response may lead to …

Immune response in human visceral leishmaniasis: analysis of the correlation between innate immunity cytokine profile and disease outcome

V Peruhype‐Magalhães… - Scandinavian …, 2005 - Wiley Online Library
… We investigated the cytokine profile of cells of the innate immune response and its …
early dominant type 2 immune response for disease onset, establishment and progression. …

Mucosal immune responses predict clinical outcomes during influenza infection independently of age and viral load

CM Oshansky, AJ Gartland, SS Wong… - American journal of …, 2014 - atsjournals.org
… but immunologic correlates of disease severity are not understood. We hypothesized that
innate cellular immune responses at the site of infection would correlate with disease outcome. …

The harms and benefits of inflammatory and immune responses in vascular disease

A Chamorro, J Hallenbeck - Stroke, 2006 - Am Heart Assoc
immune response that leads to local inflammation and both innate and adaptive immune
responses. … and antifungal immunity in Drosophila 15 initiate and orchestrate inflammatory and …

Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression

MC Dubinsky, YC Lin, D Dutridge… - Official journal of the …, 2006 - journals.lww.com
… or indicator of disease progression. We hypothesize that the presence and magnitude of
immune responses to … Disease progression to IP/S was the primary outcome in this study. These …

The immune response in tuberculosis

A O'Garra, PS Redford, FW McNab… - Annual review of …, 2013 - annualreviews.org
… factors that together play a critical role in determining the outcome of the immune
response to M. tuberculosis infection (119, 123, 124). After infection of the host with M. …

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

SL Klein - Bioessays, 2012 - Wiley Online Library
… are typically higher in males, whereas disease outcome can be worse for females. Females
mount higher innate and adaptive immune responses than males, which can result in faster …