Challenges and strategies: the immune responses in gene therapy

H Zhou, D Liu, C Liang - Medicinal research reviews, 2004 - Wiley Online Library
… A full description of the immune-gene therapy of cancer described to date is beyond the scope
… on discussing the challenges caused by the immune responses in gene therapy and the …

Gaining insights on immune responses to the novel coronavirus, COVID-19 and therapeutic challenges

M Hajivalili, M Hosseini, M Haji-Fatahaliha - Life Sciences, 2020 - Elsevier
… particles from the body, while dysregulated immune responses result in viral spreading,
multi-… roles of immune responses in COVID-19 in the terms of innate and adaptive immunity. …

Radiation effects on antitumor immune responses: current perspectives and challenges

T Walle, R Martinez Monge… - Therapeutic …, 2018 - journals.sagepub.com
… promoting an effective antitumor immune response. Cell death … Moreover, a systemic
immune response can be elicited or … effects of RT on the antitumor immune response (Figure 1). …

Cancer and immune response: old and new evidence for future challenges

L de la Cruz-Merino, E Grande-Pulido… - The …, 2008 - academic.oup.com
immune system tolerance. Recent studies have confirmed the occurrence of spontaneous
and induced antitumor immune responses … boosters of the immune response through tumor-…

[HTML][HTML] The challenge for gene therapy: innate immune response to adenoviruses

B Thaci, IV Ulasov, DA Wainwright, MS Lesniak - Oncotarget, 2011 - ncbi.nlm.nih.gov
… understanding the innate immune response as a result of adenoviral entry by dissecting the
major pathways involved. Of the many independent receptors in innate immunity, two stand …

[HTML][HTML] Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: perspectives and challenges

ML Michel, Q Deng, M Mancini-Bourgine - Journal of hepatology, 2011 - Elsevier
immune responses. We also describe innovative strategies for generating functional immune
responses … However, the immune responses accounting for this therapeutic effect were not …

[HTML][HTML] Metabolic regulation of immune responses: therapeutic opportunities

N Assmann, DK Finlay - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
… hours to days of an immunological challenge, M2 macrophages are longer lived and have
important roles within the resolution phase of the immune response and in tissue repair and …

Oncolytic virus delivery modulated immune responses toward cancer therapy: Challenges and perspectives

M Keshavarz, SM Miri, E Behboudi, Y Arjeini… - International …, 2022 - Elsevier
… different OV delivery systems in terms of the stimulation of antitumor immune responses
and to briefly discuss the strategies used to help OV escape from host immune responses. …

[HTML][HTML] Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - … and targeted therapy, 2020 - nature.com
… well-coordinated immune response represents the first line of defense against viral infection,
excessive inflammatory innate response and impaired adaptive host immune defense may …

Immune response to helper dependent adenoviral mediated liver gene therapy: challenges and prospects

MP Seiler, V Cerullo, B Lee - Current gene therapy, 2007 - ingentaconnect.com
… We focus on the complex immune response and consequences of systemic vector delivery
… disease therapy. Future development of interventions to avoid the innate immune response, …