Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
… In summary, because the innate immune response harbors the capacity to induce broad-…
drives much of COVID-19 pathology, therapeutic targeting of the innate immune system in SARS…

[HTML][HTML] Immunopathology of SARS-CoV-2 infection: immune cells and mediators, prognostic factors, and immune-therapeutic implications

A Allegra, M Di Gioacchino, A Tonacci… - International journal of …, 2020 - mdpi.com
… an effective immune response. Such balance is altered in COVID-19 critical patients with …
further showing the severity of the immune system impairment in these subjects. SARS-CoV-2 …

[HTML][HTML] Severe COVID-19: what have we learned with the immunopathogenesis?

B Bordallo, M Bellas, AF Cortez, M Vieira… - Advances in …, 2020 - SciELO Brasil
… by severe acute respiratory syndrome coronavirus 2 (SARS-… on immunopathogenesis
associated with severe COVID-19, … to the dysregulated immune response against the SARS-CoV…

[HTML][HTML] Prospects and opinions in immunopathogenesis of COVID-19

FHO Al-Khikani - Matrix Science Medica, 2021 - journals.lww.com
… In multiple viral infections, the immunopathological effects of … and activation of a strong
inflammatory response. Worryingly, a … effect of the immune response against COVID 19 have been …

Illuminating the immunopathology of SARS‐CoV‐2

S Saksena, P Chattopadhyay - Cytometry Part B: Clinical …, 2021 - Wiley Online Library
… our understanding of the COVID-19 immunopathology. A recent … the antigen-specific adaptive
immune response to SARS-CoV-2 … the immune system has been interrogated in COVID-19

[HTML][HTML] Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
… Thus, as discussed in this review, treatments addressing the immunopathology of the
infection, such as immunomodulatory drugs approved for different clinical indications, have …

TLRs in COVID-19: How they drive immunopathology and the rationale for modulation

FL Mabrey, ED Morrell, MM Wurfel - Innate immunity, 2021 - journals.sagepub.com
… Upon infection with SARS-CoV-2, the virus that causes COVID-19, an innate immune
response is activated through the phylogenetically preserved TLR family. TLRs are germline …

[HTML][HTML] Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
immunopathological host response and the mechanistic role of viral proteins in the active
manipulation of the host immune system. … immunopathology in coronavirus infections 19,22 . …

Dendritic cells in COVID-19 immunopathogenesis: insights for a possible role in determining disease outcome

RC Borges, MS Hohmann… - … Reviews of Immunology, 2021 - Taylor & Francis
… In COVID-19 there are indications that a specific adaptive immune response is also … of
dendritic cells in the immune response against the SARS-CoV-2 in a patient that recovered from …

[HTML][HTML] Cellular immune response to COVID-19 and potential immune modulators

X Zhou, Q Ye - Frontiers in immunology, 2021 - frontiersin.org
immune responses during COVID-19, we suggest that type I interferon (IFN) could be
administered to patients with severe COVID-19 … administered in the immune hyperactivation stage. …