Early combination therapy of COVID-19 in high-risk patients

HM Orth, C Flasshove, M Berger, T Hattenhauer… - Infection, 2023 - Springer
Molnupiravir-nirmatrelvir/ritonavir was more effective in vitro … In a case series of
immunocompromised patients, the addition … Treatment algorithms differed between the four …

Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients

A Jayk Bernal, MM Gomes da Silva… - … England Journal of …, 2022 - Mass Medical Soc
… modified intention-to-treat population, participants receiving molnupiravir had a lower risk of
… 709 participants) in the molnupiravir group as compared with 9.7% (68 of 699 participants) …

Multidrug-resistant mutations to antiviral and antibody therapy in an immunocompromised patient infected with SARS-CoV-2

Y Hirotsu, H Kobayashi, Y Kakizaki, A Saito, T Tsutsui… - Med, 2023 - cell.com
… has been shown to be effective in treating COVID-19. Remdesivir and molnupiravir target
RNA-dependent RNA polymerase (RdRp), while nirmatrelvir targets 3 chymotrypsin-like …

Molnupiravir and nirmatrelvir/ritonavir: tolerability, safety, and adherence in a retrospective cohort study

M Mazzitelli, D Mengato, L Sasset, A Ferrari, S Gardin… - Viruses, 2023 - mdpi.com
… hypersensitivity reaction (2 treated with molnupiravir and 1 treated with nirmatrelvir/ritonavir). …
We thank all the patients and staff from the Infectious Diseases Unit for participating in this …

Favipiravir for treatment of outpatients with asymptomatic or uncomplicated coronavirus disease 2019: a double-blind, randomized, placebo-controlled, phase 2 trial

M Holubar, A Subramanian, N Purington… - Clinical Infectious …, 2022 - academic.oup.com
… We randomized 149 participants with 116 included in the … placebo-controlled trial of
molnupiravir reported an approximate 30… Finally, we did not include severely …

[HTML][HTML] Oral antivirals for COVID-19 among patients with cancer

D Guermazi, P Arvanitis, K Vieira, JL Warner… - Research …, 2024 - ncbi.nlm.nih.gov
… -free oral treatment against COVID-19 in immunosuppressed patients taking …
immunocompromised participants in a post hoc analysis from the MOVE-OUT trial, molnupiravir

Clinical experience of treatment of immunocompromised individuals with persistent SARS-CoV-2 infection based on drug resistance mutations determined by …

H Shimazu, D Wada, S Maruyama, A Inoue… - BMC Infectious …, 2023 - Springer
… of action, molnupiravir induces a number of genetic mutations after treatment; however, it has
… In the present study, nine patients also received molnupiravir, but only three showed new …

Effectiveness of molnupiravir and nirmatrelvir–ritonavir in hospitalized patients with COVID-19: a target trial emulation study

EYF Wan, VKC Yan, AHY Mok, B Wang… - Annals of internal …, 2023 - acpjournals.org
… A total of 78 of 13 795 participants (0.6%) in the molnupiravir … that molnupiravir and
nirmatrelvir–ritonavir treatments were … /ritonavir in hospitalized immunocompromised patients has …

Nirmatrelvir/ritonavir or Molnupiravir for treatment of non-hospitalized patients with COVID-19 at risk of disease progression

AA Butt, P Yan, OS Shaikh - Plos one, 2024 - journals.plos.org
… Since there was no contact with any of the participants, and due to its exempt status, the …
Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-…

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

JF Standing, L Buggiotti, JA Guerra-Assuncao… - Nature …, 2024 - nature.com
… A716V was absent in Usual Care but present at <10% allele frequency during or just after
treatment in a further six molnupiravir-treated participants, none of whom had detectable viral …