The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
… We review the intricacies of COVID-19 pathophysiology… COVID-19 and respiratory failure
of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19

COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study

A Jurado, MC Martín, C Abad-Molina, A Orduña… - Immunity & …, 2020 - Springer
immunity would become exhausted and a strong but ineffective and almost deleterious innate
response would account for COVID-19 … effect in regards to COVID-19 severity in our series. …

[HTML][HTML] COVID-19, asthma, and biological therapies: what we need to know

M Morais-Almeida, R Aguiar, B Martin… - World Allergy …, 2020 - Elsevier
… their primary effects by inhibiting T2 immunity. The question is whether reduction of T2
mechanisms is beneficial or harmful in COVID-19 susceptibility or progression perhaps through …

Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome

D Weiskopf, KS Schmitz, MP Raadsen, A Grifoni… - … immunology, 2020 - science.org
… We included 10 COVID-19 patients with moderate to severe ARDS in this study and compared
these with 10 age-… 1 Clinical overview of moderate to severe COVID-19 ARDS patients. …

Immunology of multisystem inflammatory syndrome after COVID-19 in children: a review of the current evidence

F Filippatos, EB Tatsi, A Michos - International Journal of Molecular …, 2023 - mdpi.com
… The activated innate, humoral and T-cell-mediated immunological pathways that lead … on
the immunological aspects of MIS-C with respect to innate, humoral, and cellular immunity. In …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
… models, but many did not produce sterilizing immunity in animal models and/or induced severe
… -2-specific humoral and cellular immunity in 8 COVID-19 patients, recently become virus-…

ACTIVATE-2: a double-blind randomized trial of BCG vaccination against COVID-19 in individuals at risk

M Tsilika, E Taks, K Dolianitis, A Kotsaki… - … in immunology, 2022 - frontiersin.org
… the efficacy of BCG vaccination against coronavirus disease 2019 (COVID-19). In this …
incidence of COVID-19 and the presence of anti–severe acute respiratory syndrome coronavirus 2 …

Immune response, inflammation, and the clinical spectrum of COVID-19

LF García - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 presents a wide spectrum of clinical manifestations, which ranges … COVID-19
and its etiological agent SARS-CoV-2, stressing the similarities with other severe coronavirus

Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID19 severity

CAS Prado, DLM Fonseca, Y Singh… - Journal of Medical …, 2023 - Wiley Online Library
COVID-19 remains primarily unexplored. Here, we performed an integrative systems
immunology … in the cell cycle signature of COVID-19 patients. We found significantly enriched cell …

[HTML][HTML] COVID-19 infection: the perspectives on immune responses

Y Shi, Y Wang, C Shao, J Huang, J Gan… - Cell Death & …, 2020 - nature.com
… The outbreak of the new coronavirus (SARS-CoV-2) infection … learned much of coronavirus
disease 2019, COVID-19, and … Clearly, the conventional wisdom based on overall immunity