… The molecular mechanism of action of IMiDs remained unclear for a long time until 2010
when the protein cereblon (CRBN) was identified as a primary direct target. IMiDs binds to …

… Immunomodulatory drugs (IMiDs) are effective treatments for patients with multiple myeloma.
IMiDs … of the role for T cells in the overall anti-myeloma effects of immunomodulatory drugs. …

… the mechanisms of action of both IMiDs and CELMoDs in CLL and B cell NHL and focus
on their effects on cellular components within the TME—their immunomodulatory activity …

… Though there is no doubt that PUFAs act at a molecular level, a variety of molecular
mechanisms were resolved only recently (fig.1). This review discusses proposed mechanisms of …

… to play a key role in the mechanism of drug resistance. This review focuses on the mechanism
of MM resistance to IMiDs and describes some promising drugs to resensitize MM cells to …

… The most common molecular mechanisms underlying such alterations are regulatory or
structural defects in various components involved in the biosynthesis and assembly of the …

… While its antibacterial mechanism of action is well-stablished (inhibiting bacterial DHPS like
most sulfonamides), there is no data analyzing the molecular mechanism underlying its anti-…

… Various studies confirmed the association of genetic changes with numerous
neurodegenerative diseases by investigating the molecular mechanisms of a particular disease. A …

… molecular mechanism of TNF-α inhibition by the second class of drugs, the immunomodulatory
drugs … class shares more of the activities of the parent drug than the SelCIDs Citation[3,4]. …

… bilirubin possesses potential immunomodulatory properties. In … bilirubin possesses powerful
immunomodulatory activity and … One of the plausible mechanisms of the immunomodulatory …