The potential role of cytokine storm pathway in the clinical course of viral respiratory pandemic

G Murdaca, F Paladin, A Tonacci, S Isola, A Allegra… - Biomedicines, 2021 - mdpi.com
The “cytokine storm” (CS) consists of a spectrum of different … Particularly in respiratory virus
infections, the cytokine storm … the phenomenon of the “cytokine storm” which determines the …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… To define the immunopathogenesis of the cytokine storm associated with the severe acute
… C and D, IL-6 blockade therapy using a humanized anti–IL-6R mAb. A humanized anti–IL-…

Autoinflammatory diseases and cytokine storms—imbalances of innate and adaptative immunity

A Marcuzzi, E Melloni, G Zauli, A Romani… - International Journal of …, 2021 - mdpi.com
… Therefore, the identification of cytokines as therapeutic targets has great relevance: … The
absence of treatment for a cytokine storm caused by COVID-19 produces immunopathogenic

Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i)

MM Pinheiro, A Fabbri, M Infante - Immunotherapy, 2021 - Future Medicine
… several pro-inflammatory cytokines (aka ‘cytokine storm’) plays … D and DPP-4 inhibitor
combination therapy (VIDPP-4i) as an … progression and modulate the cytokine storm in COVID-19. …

[HTML][HTML] Cytokine storm intervention in the early stages of COVID-19 pneumonia

X Sun, T Wang, D Cai, Z Hu, H Liao, L Zhi, H Wei… - Cytokine & growth factor …, 2020 - Elsevier
… of multiple cytokines appears to trigger a cytokine storm that produces immunopathogenic
… In view of the above observations, therapeutic strategies to treat the cytokine storm in the …

SARS-CoV-2: Insights from the Immunopathogenesis and Current Clinical Diagnosis and Therapeutic Strategies

S Sharma, U Sharma… - Journal of …, 2021 - immunologyresearchjournal.com
… the commonly witnessed cytokine storm and immune evasion. Furthermore, we discuss the
scope of present clinical diagnostic approaches and preventive/ therapeutic strategies. The …

… of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
… with FcR, resulting in the activation of macrophages and the secretion of chemokines and
other cytokines, which contribute to the immunopathogenesis and disease enhancement. …

[PDF][PDF] IMMUNOPATHOGENESIS AND POSSIBLE THERAPEUTIC INTERVENTIONS FOR COVID-19: AN UPDATE

S Mateen, A Mateen, A Khalid, AF Faizy, S Shahzad… - 2021 - rjlbpcs.com
… Elderly people and those individuals with other complications are more prone to the
development of this severe disease due to cytokine storm associated acute respiratory distress …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
… and against the role of the cytokine storm in the pathology of … of the cytokine storm and
immunomodulatory therapies to … of a cytokine storm, namely, immunopathogenesis caused by …

Role for anti-cytokine therapies in severe coronavirus disease 2019

LF Buckley, GF Wohlford, C Ting… - Critical care …, 2020 - journals.lww.com
… Our knowledge of the immunopathogenesis of coronavirus disease 2019 is evolving and
anti-cytokine therapies are under active investigation. This narrative review summarizes …