Therapeutic role of tocilizumab in SARS-CoV-2-induced cytokine storm: rationale and current evidence

C Pelaia, C Calabrese, E Garofalo, A Bruni… - International Journal of …, 2021 - mdpi.com
… COVID-19-associated cytokine storm. In this regard, the IL-6 receptor antagonist tocilizumab,
… article aims to discuss the immunopathology of the cytokine storm caused by SARS-CoV-2 …

[HTML][HTML] Severe COVID-19: what have we learned with the immunopathogenesis?

B Bordallo, M Bellas, AF Cortez, M Vieira… - Advances in …, 2020 - SciELO Brasil
… response, lymphocyte exhaustion and cytokine storm that ultimately lead to … therapeutic
strategies. In this narrative review, the authors aimed to describe the immunopathogenesis of …

Cytokine storm in COVID-19 and other diseases: emerging therapeutic interventions

S Sahu, R Dharra, M Gun, S Datta, AK Akela, A Kumar - Stem Cells, 2024 - Elsevier
… In CS, the immune system produces elevated proinflammatory cytokines’ … cytokines that
result in the abnormal immune response by the host. This chapter includes different therapeutic

[HTML][HTML] Current concepts on immunopathology of COVID-19 and emerging therapies

L Azimi, A Karimi, M Alebouyeh, A Shirvani… - Archives of Pediatric …, 2020 - brieflands.com
… on the immunopathogenicity of SARS-… cytokine storm and inflammation, and diminished T
lymphocytes count were reported as possible mechanisms for the virus immunopathogenesis. …

Dynamics of a cytokine storm

HH Yiu, AL Graham, RF Stengel - 2012 - journals.plos.org
Cytokines allow context-dependent communication within the body [1], [2], [3], [4], [5]. If the
interactions that lead to cytokine production are destabilized, a "cytokine storm" (or … to therapy. …

Spotlight on Immunity against COVID-19 with Emphasis on Cytokine Storm

AM Aldahlawi, KSA Zaher - Pharmacophore, 2021 - pharmacophorejournal.com
… system for immunopathogenesis is present. No … of cytokine responses to a cytokine storm
or pathogenic CRS. Thereby, targeting therapy to interrupt the development of cytokine storms

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
… to the generation of cytokine storm and organ dysfunction. The … of the sepsis-associated
cytokine storm and discusses various … for developing novel therapeutic drugs for cytokine storm-…

[PDF][PDF] Mechanism of Cytokine Storm in COVID-19: How can probiotics combat it

MS Reddy - JAAPI, 2021 - aapiusa.org
cytokine storm induced by it. Such understanding will aid in developing both preventive and
therapeutic … genesis and pathophysiology of lethal cytokine storm during COVID-19 infection…

Targeting cytokine storm as the potential anti-viral therapy: Implications in regulating SARS-CoV-2 pathogenicity

S Maity, A Santra, AV Hebbani, S Pulakuntla… - Gene, 2023 - Elsevier
therapeutic strategy. This review focuses on the potential targeting of COVID-19 associated
cytokine storm and … effects, which is a known factor in the immunopathogenesis of COVID-19. …

[PDF][PDF] Cytokine Storm in Novel Corona Virus Disease (COVID-19)

M Begum - PSYCHOLOGY AND EDUCATION, 2021 - pdfs.semanticscholar.org
… trials and studies suggest that this cytokine storm is related with increased intensity of … the
immunopathogenesis of the COVID-19 cytokine storm in the search of proper therapy of COVID …