Immunotherapeutic implications of IL-6 blockade for cytokine storm

T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Future Medicine
… therapy, strongly suggest that IL-6 blockade may constitute an … a ‘cytokine storm’. This review
focuses on the pathological role of IL-6 in a cytokine storm and the therapeutic effect of IL-6

[HTML][HTML] Cytokine storm in COVID-19:“when you come out of the storm, you won't be the same person who walked in”

V Castelli, A Cimini, C Ferri - Frontiers in immunology, 2020 - frontiersin.org
… After SARS-CoV infection, a high virus load and exaggerated immune response lead to an
inflammatory cytokine storm, accompanied by immunopathological alterations in the lungs …

Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection

S Keam, D Megawati, SK Patel, R Tiwari… - Reviews in Medical …, 2020 - Wiley Online Library
… the response of the host immune system and the immunopathology of SARS-CoV-2 infection
as … , and cytokine storm have been discussed as part of immunopathology mechanisms in …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
cytokine storm in its severest form has been marked by elevation of IL-6, IL-10, TNF-α, and
other cytokines … This review highlights our current state of knowledge of immune mechanisms

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
… fatal cytokine storm syndrome (CSS), which have increased interest in CSS’s mechanisms,
… hemophagocytic syndrome, cytokine release syndrome (CRS), and cytokine storm (CS). …

[HTML][HTML] The roles of neutrophils in cytokine storms

L Chan, N Karimi, S Morovati, K Alizadeh, JE Kakish… - Viruses, 2021 - mdpi.com
cytokine storm is an abnormal discharge of soluble mediators following an inappropriate
inflammatory response that leads to immunopathological … can contribute to cytokine storms, this …

Role of the innate cytokine storm induced by the influenza A virus

Y Gu, ACY Hsu, Z Pang, H Pan, X Zuo, G Wang… - Viral …, 2019 - liebertpub.com
… are complicated by several types of cytokines and … causes cytokine networks to form; these
networks determine the outcome of viral infections. In this review, we focus on cytokine storms

[HTML][HTML] Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

A Ciabattini, P Garagnani, F Santoro… - … in immunopathology, 2020 - Springer
… the risk of COVID-19-related “cytokine storm syndrome” with an overlap between the factors
… The complex and still unclear immunopathological mechanisms of SARS-CoV-2 infection, …

[HTML][HTML] COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
… and the uncontrolled release of cytokines [2]. The phrase “cytokine storm” is a descriptive
term to … Cytokine storms can cause a severe clinical complication known as acute respiratory …

[HTML][HTML] Immunopathogenesis of different emerging viral infections: evasion, fatal mechanism, and prevention

B Yang, KD Yang - Frontiers in Immunology, 2021 - frontiersin.org
… of untoward cytokines causing cytokine storm of immunopathology. Because … cytokine
storms in different emerging infections are frequently associated with augmented levels of IL-6