Immunotherapeutic implications of IL-6 blockade for cytokine storm

T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Future Medicine
… therapy, strongly suggest that IL-6 blockade may constitute an … a ‘cytokine storm’. This review
focuses on the pathological role of IL-6 in a cytokine storm and the therapeutic effect of IL-6

Immunotherapy summary for cytokine storm in COVID-19

Y Li, W Zhao, J Liu, Z Chen, Q Lv… - Frontiers in Pharmacology, 2021 - frontiersin.org
… Targeting certain key cytokines in CS, using their monoclonal antibodies, and recombinant
… them and block their pro-inflammatory effects, is an effective strategy to treat cytokine storms. …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (… the effects of …

Constitutive inflammatory cytokine storm: a major threat to human health

KK Gupta, MA Khan, SK Singh - Journal of Interferon & Cytokine …, 2020 - liebertpub.com
… Sustained release of cytokines due to immunotherapy or hormonal issues causes various
… This review will focus on the inflammatory cytokine storm and its implications on human …

Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… Understanding the pathogenesis of cytokine storm will help … an overview of the cytokine storm
and its implications in COVID-… paper provides critical insights on cytokine storm from both a …

[HTML][HTML] Radiotherapy and cytokine storm: risk and mechanism

C Zhang, Z Liang, S Ma, X Liu - Frontiers in Oncology, 2021 - frontiersin.org
… can also induce cytokine storms, such as Chimeric antigen receptor (CAR) T immunotherapy
(1). It has … All of the above immune activation effects could induce cytokine storm potentially. …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
… Therefore, different strategies are employed to mitigate the effects of CS. These include
using monoclonal antibodies directed against soluble cytokines or the cytokine receptors, …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… If the inflammatory reaction is very pronounced, an ultimately uncontrolled release of
proinflammatory cytokines leads to cytokine storm with the known potentially lethal courses [168]. …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
… The ability of T lymphocytes to initiate a cytokine storm is well exemplified by the effects
of the iatrogenic hyperactivation of these cells in the context of CAR T cell and anti-CD28 …

Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… of cytokine storms. It is therefore becoming apparent that a combination therapy approach
involving an antimicrobial compound along with an immunotherapy … has beneficial effects on …