[HTML][HTML] SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
cells targeted by SARS-CoV-2 during natural infection in humans are likely to be multiciliated
cells in the nasopharynx or trachea, or sustentacular cells … the positive-sense SARS-CoV-2 …

Cell entry mechanisms of SARS-CoV-2

J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
… , cell infectivity, and wide spread of the virus. This study also clarifies conflicting reports
from recent studies on cell entry of SARS-CoV… step of viral infection: the cell entry of SARS-CoV-2. …

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - … reviews Molecular cell …, 2022 - nature.com
… their biosynthesis in the infected cells, while the S protein of other coronaviruses is cleaved
only when they reach the next target cell. SARS-CoV-2, like MERS-CoV, belongs to the first …

Coronaviruses and sars-cov-2

M Hasöksüz, S Kilic, F Saraç - Turkish journal of medical …, 2020 - journals.tubitak.gov.tr
… While the E protein is plentifully expressed inside the infected cell during the replication
cycle, only a small portion is incorporated into the virion envelope [11]. Most of the protein is …

Syncytia formation by SARSCoV‐2‐infected cells

J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
… The viral and cellular mechanisms regulating the formation of … that SARS-CoV-2-infected
cells express the Spike protein (S) at their surface and fuse with ACE2-positive neighboring cells

SARS-CoV-2 spreads through cell-to-cell transmission

C Zeng, JP Evans, T King, YM Zheng… - Proceedings of the …, 2022 - National Acad Sciences
… Compared with cell-free infection, cell-to-cell transmission of SARS-CoV-2 is refractory to
inhibition by neutralizing antibody or convalescent sera of COVID-19 patients. While …

[HTML][HTML] SARS-CoV-2 cell tropism and multiorgan infection

J Liu, Y Li, Q Liu, Q Yao, X Wang, H Zhang, R Chen… - Cell discovery, 2021 - nature.com
… e Schematic of SARS-CoV-2 multiorgan infection and cell tropism in the human body. …
The fact that SARS-CoV-2 infection in the vascular endothelial cells of various organs induces …

[HTML][HTML] Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

D Bojkova, K Klann, B Koch, M Widera, D Krause… - Nature, 2020 - nature.com
… viral replication in cells. Our results reveal the cellular infection profile of SARS-CoV-2 and
… that underlie the modulation of host cells after infection with SARS-CoV-2. Furthermore, our …

[HTML][HTML] SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova… - Nature, 2021 - nature.com
… We noted desquamation of pneumocytes as early as two days after infection; a large
number of virally infected cells were fully detached or detaching from the alveolar basement …

Endothelial cells are not productively infected by SARSCoV‐2

L Schimmel, KY Chew, CJ Stocks… - Clinical & …, 2021 - Wiley Online Library
… of SARS-CoV-2. We also show that SARS-CoV-2 does not infect endothelial cells in 3D …
that in a co-culture model endothelial cells are not infected with SARS-CoV-2. Endothelial …