Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
… response and produce inflammatory cytokines. We also … -γ–mediated PANoptosis can drive
cytokine storm and severity in … immune system and inflammatory cell death will be critical to …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
cytokine release and cell death pathways; certain cytokines, … ), can activate inflammatory cell
death, leading to further cytokineinflammatory cell death, providing insights into the cellular

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… the cytokine storm are … cytokine storm is a potentially fatal immune disease characterized
by the high-level activation of immune cells and excessive production of massive inflammatory

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

R Karki, SJ Lee, R Mall, N Pandian, Y Wang… - Science …, 2022 - science.org
… sensor that drives inflammatory cell death in response to IFN … robust ZBP1-dependent
inflammatory cell death, PANoptosis, … that ZBP1 drives cell death, cytokine storm, and lethality in β-…

Coronaviruses: innate immunity, inflammasome activation, inflammatory cell death, and cytokines

SJ Lee, R Channappanavar, TD Kanneganti - Trends in immunology, 2020 - cell.com
… In this review, we focus on our present understanding of innate immune responses,
inflammasome activation, inflammatory cell death pathways, and cytokine secretion during SARS-…

[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
cytokine shock. Collectively, our findings suggest that blocking the cytokine-mediated
inflammatory cell death … linking cytokine storm to organ damage is the process of cell death. …

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
… -inflammation and cytokine storm highlights the necessity of early identification of
cytokine storm and implementation of anti-inflammatory treatment. Timely control of hyper-inflammatory

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
cellular components of the immune response corroborating with changes in cytokine levels
while discussing cytokine … brief potential therapies attempting to modulate the cytokine storm. …

Characterizing the Crosstalk Between Programmed Cell Death Pathways in Cytokine Storm With an Agent-Based Model

S Feuerwerker, RC Cockrell, G An - Surgical Infections, 2023 - liebertpub.com
… Instead, we focus on the initial infection and subsequent inflammatory events related to
programmed cell death (PCD). For each component represented in the PCDABM, we reviewed …

Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
cytokine storm is a systemic inflammatory response to infections and drugs and leads to
excessive activation of immune cells and the generation of pro-inflammatory cytokinescell death