Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
… , CD4 + T lymphocytes are rapidly activated to become pathogenic T helper (Th) 1 cells and
… The cytokine environment induces inflammatory CD14 + CD16 + monocytes with a high …

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

Y Zhou, B Fu, X Zheng, D Wang, C Zhao, Y Qi, R Sun… - biorxiv, 2020 - biorxiv.org
… by pathogenic T cells and inflammatory monocytes may … increased plasma concentrations
of inflammation related cytokines, … ), monocyte chemoattractant protein 1(MCP1), macrophage …

Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of Tcell responses

F Geissmann, C Auffray, R Palframan… - Immunology and cell …, 2008 - Wiley Online Library
… Tip-DC and inflammatory CD115 + Gr1 + monocytes have also been reported in … Pathogen
are digested, processed and presented to T cells as antigenic peptide, either by monocyte

Glucose metabolism in T cells and monocytes: new perspectives in HIV pathogenesis

CS Palmer, CL Cherry, I Sada-Ovalle, A Singh… - …, 2016 - thelancet.com
Inflammatory activation of T cells is accompanied by increased energy requirements via
glycolysis, needed for the surge in cytokine production and differentiation into Th1 and …

Inflammatory monocytes and the pathogenesis of viral encephalitis

RL Terry, DR Getts, C Deffrasnes… - Journal of …, 2012 - Springer
… of inflammatory monocyte trafficking to the brain and addresses the role of these cells in viral
… engage in a number of potent effector functions including antigen presentation and T cell

[HTML][HTML] Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis

…, E Donders, R Schepers, T Van Brussel… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
… the T-cell response, we subclustered all 65,293 T cells and … pathogenic T H17.1 cells and
pro-inflammatory monocytes. … therapy tackles monocyte-mediated tissue inflammation, and …

Functional phenotype of synovial monocytes modulating inflammatory T-cell responses in rheumatoid arthritis (RA)

BR Yoon, SJ Yoo, YH Choi, YH Chung, J Kim, IS Yoo… - PloS one, 2014 - journals.plos.org
… that inflammatory monocytes influence T cell polarization and expansion and shape T-cell
function as antigen presenting cells to promote pathogenic CD4 T cell responses at sites of …

CXCR3-Dependent CD4+ T Cells Are Required to Activate Inflammatory Monocytes for Defense against Intestinal Infection

SB Cohen, KJ Maurer, CE Egan, S Oghumu… - … pathogens, 2013 - journals.plos.org
pathogen, to study the requirements for inflammatory macrophage activation in the intestinal
mucosa. We find that CD4 + T lymphocytes… of intestinal mucosa inflammatory monocytes via …

Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells

A Pommier, A Audemard, A Durand… - Proceedings of the …, 2013 - National Acad Sciences
… All these mice were maintained in our specific pathogen free animal facility. All experiments
were approved by the Paris-Descartes Ethical Committee for Animal Experimentation (…

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

G Gallina, L Dolcetti, P Serafini… - The Journal of …, 2006 - Am Soc Clin Investig
… + IL-4Rα + ), inflammatory-type monocytes that is elicited by growing tumors and activated
by IFN-γ released from T lymphocytes. CD11b + IL-4Rα + cells produced IL-13 and IFN-γ and …