… SASP activation, resulting in senescence. Our results demonstrate that the SASP can cause paracrinesenescence and impact on tumour suppression and senescence in vivo. …
S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
… sustains a senescence-associated inflammatoryresponse, we attempted to eliminate senescent cells in Syrian hamsters by using senolytic drugs that can selectively kill senescent cells…
… or inappropriate activation of senescence contributes to tumour progression and malignancy. This review will discuss the paracrine effects of senescent cells on different aspects of …
… by the senescent tumor cells and the senescent … senescence-associated inflammatory responses in aging and cancer. We propose that controlling senescence-associated inflammation …
A Freund, AV Orjalo, PY Desprez, J Campisi - Trends in molecular …, 2010 - cell.com
… Normally, the inflammatoryresponse ceases within hours or days, once the foreign … of senescent cells as a possible additional source. We describe the known effects of the senescence-…
JL Ren, JS Pan, YP Lu, P Sun, J Han - Cellular signalling, 2009 - Elsevier
… in senescent cells mimic the inflammatoryresponse and wound repair process. The inflammatory state of cellular senescence … by senescent cells also have paracrine functions. They …
MK Ruhland, LM Coussens, SA Stewart - Biochimica et Biophysica Acta …, 2016 - Elsevier
… of the senescence-induced inflammatoryresponses in the context of cancer. A more complete understanding of senescence … phenotype to neighboring cells via paracrine mechanisms …
J Platas, MI Guillén, MDP Del Caz, F Gomar… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
… stem cells may regulate senescence features induced by inflammatory stress in OA … down-regulated senescence markers induced by interleukin-1β including senescence-associated β-…
X Long, Y Li, M Yang, L Huang, W Gong… - Journal of …, 2016 - Am Soc Microbiol
… -γ drive the antiviral response and senescence (8, 51). … inflammatoryresponses by BZLF1 during the EBV lytic life cycle is required to attenuate the transmission of paracrinesenescence…