Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
… The cytokine storm can also be mediated either by ACE2-mediated inflammatory response,
by cell pyroptosis or by the delayed release of Type I IFNs. Cell pyroptosis is caused due to …

[HTML][HTML] Specific cytokines in the inflammatory cytokine storm of patients with COVID-19-associated acute respiratory distress syndrome and extrapulmonary multiple …

J Wang, X Yang, Y Li, J Huang, J Jiang, N Su - Virology journal, 2021 - Springer
… an uncontrolled inflammatory response during ARDS, and this response functions … inflammatory
cytokine storm in COVID-19 patients with ARDS and DIC. We found that the levels of IL-6

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
… , it has been suggested that a cytokine storm of hyper-inflammation is responsible for this …
therapies which target the COVID-19 induced cytokine storm. As this is not exclusive to COVID-…

[HTML][HTML] Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position …

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… In this article, we present an overview of the cytokine storm … paper provides critical insights
on cytokine storm from both a … inflammatory response to viral or bacterial infection. Elevated …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
… SARS-CoV-2 mediated cytokine storm is associated with the mortality and morbidity of
COVID-19 patients. The key cytokines implicated in the onset of disease severity include TNF-α, …

Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications

R Hirawat, MA Saifi, C Godugu - Life sciences, 2021 - Elsevier
… PPAR-γ agonists not only down regulate the inflammatory response induced by cytokine
storm but also promote their survival in mouse model of H1N1 influenza virus [94]. Sirtuin 1 …

Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
… CS are the cornerstone of treatments for cytokine storms and macrophage activation … forms
of CRS to curb the systemic inflammatory response and prevent the occurrence of ARDS, if …

The cytokine storm of severe influenza and development of immunomodulatory therapy

Q Liu, Y Zhou, Z Yang - Cellular & molecular immunology, 2016 - nature.com
… effective in the therapy of severe influenza-induced cytokine storm. However, these agents
can inhibit the inflammatory response induced by angiotensin II and improve the survival of …

[HTML][HTML] Regulation of inflammatory cytokine storms by mesenchymal stem cells

L Wang, Y Li, M Xu, Z Deng, Y Zhao, M Yang… - Frontiers in …, 2021 - frontiersin.org
… are secreted to regulate the degree of the inflammatory response so that the body can not
only remove harmful stimuli but also maintain cellular homeostasis (25–27). However, when …

Clinical features of cytokine storm syndrome

M Shimizu - Cytokine storm syndrome, 2019 - Springer
… and dysfunctional immune response involving the … of cytokines, causing a cytokine storm.
Many clinical features of CSS can be explained by the effects of proinflammatory cytokines, …