HIF-1 in the inflammatory microenvironment

N Dehne, B Brüne - Experimental cell research, 2009 - Elsevier
… Though detailed mechanisms are unclear, continuing local inflammatory responses and
activation of HIF are both associated with cancer progression. It is likely that inflammatory cells …

NF‐κB and HIF crosstalk in immune responses

L D'Ignazio, D Bandarra, S Rocha - The FEBS journal, 2016 - Wiley Online Library
… Although HIF is mainly associated with the hypoxia response, the last few years … for HIF in
the inflammation response. Numerous studies have shown that HIF- is induced in response

Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines

MI Malkov, CT Lee, CT Taylor - Cells, 2021 - mdpi.com
HIF-dependent signaling at sites of inflammation. We report extensive evidence for these
cytokines directly impacting upon HIF signaling through the regulation of HIFinflammatory and …

Role of HIF-1 and NF-κB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals

L Tacchini, E Gammella, C De Ponti, S Recalcati… - Journal of Biological …, 2008 - ASBMB
… dependent ferroportin down-regulation (eg iron uptake) may be important for iron sequestration
within reticuloendothelial cells during the very early phase of the inflammatory response. …

HIF-promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
… in glycolysis and inflammatory response, 12 our data suggests that HIF-1 … inflammatory
responses. Notably, 10 genes in the HIF- pathway, including the hypoxia-inducible factor- (…

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

R Feinman, EA Deitch, AC Watkins… - American Journal …, 2010 - journals.physiology.org
… Given that HIF-1 is capable of modulating the innate immune and inflammatory responses
in hematopoietic and nonhematopoietic cells, we determined whether HIF-1 activation …

HIF-is essential for myeloid cell-mediated inflammation

T Cramer, Y Yamanishi, BE Clausen, I Förster… - Cell, 2003 - cell.com
… the critical role of HIF- in infiltration at the very earliest stages of inflammatory cell recruitment.
We present evidence that HIF- controls inflammatory response through its regulation …

IGF-1 induced HIF--TLR9 cross talk regulates inflammatory responses in glioma

S Sinha, N Koul, D Dixit, V Sharma, E Sen - Cellular signalling, 2011 - Elsevier
HIF- links inflammatory and oncogenic pathways in GBM, we investigated whether IGF-1
affects HIF- to regulate inflammatory response … ) regulated HIF- transcriptional activity …

HIF-1 expression in healing wounds: HIF-induction in primary inflammatory cells by TNF-α

JE Albina, B Mastrofrancesco… - … of Physiology-Cell …, 2001 - journals.physiology.org
hypoxia-inducible factor (HIF)-1 during acute inflammation was investigated in experimental
wounds. HIF-HIF- protein was detectable in wound cells 1 and 5 days after injury. …

[PDF][PDF] HIF-promotes inflammatory response of chronic obstructive pulmonary disease by activating EGFR/PI3K/AKT pathway.

HX Zhang, JJ Yang, SA Zhang… - European Review for …, 2018 - europeanreview.org
inflammation obstruction in airways. This study aims to explore the regulatory mechanism
of hypoxia-inducible factor- (HIF-) in inflammatory response and progression of COPD. …