… from blood-borne toxins, proteins, and cells is critical to the brain’s … brain barrier (BBB)
function accompanies many neurologic disorders, and is tightly associated with brain inflammatory …

… neurons while signaling the presence of systemic inflammation and infection to the brain
to … and duration of systemic inflammation, the vascular blood–brain barrier becomes more …

… of systemic inflammation on the blood-brain barrier (BBB), which may be desirable or
deleterious. The foremost role of the BBB is to maintain homeostasis for optimal brain function. …

… understanding of the intracellular signaling pathways that lead to BBB dysfunction for the
purpose … inflammatory mediators and related intracellular signaling pathways that lead to BBB …

… The brain's response to acute injury is characterized by increased permeability of the
blood-brain barrier (BBB) and pro-inflammatory microglia signaling, both of which have been …

… alterations of CNS barriers. Barrier dysfunction can contribute to neurological disorders in a
… in an active way by guiding the migration of inflammatory cells into the CNS. Both ways may …

An intact functioning blood–brain barrier (BBB) is … Inflammatory damage to the unique
microvascular endothelial cell … disorders ranging from ischaemic stroke and traumatic brain injury, …

… brain injury. A large body of evidence indicates that postischemic inflammation is associated
with acute blood-brain barrier (… of the IL-17A receptor signaling on synergistic stimulation by …

… blood–brain barrier (BBB) dysfunction, which is characterized by inflammation and leakage.
… anxiety and depression with associated BBB inflammation and leakage. Critical therapeutic …

… locally, which subsequently activate endothelial IL-1R1 signaling that induces T cell recruitment
and exacerbates CNS inflammation. Monocytes may migrate across the BBB depending …