Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
… , CD4 + T lymphocytes are rapidly activated to become pathogenic T helper (Th) 1 cells
and generate GM-CSF, etc. The cytokine environment induces inflammatory CD14 + CD16 + …

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

Y Zhou, B Fu, X Zheng, D Wang, C Zhao, Y Qi, R Sun… - biorxiv, 2020 - biorxiv.org
… These phenomena suggest severe pulmonary inflammation and cytokine storm also exist
in 2019-nCoV infection. At present, symptomatic treatments with organ support to moribund …

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

R Channappanavar, S Perlman - Seminars in immunopathology, 2017 - Springer
T cells to apoptosis resulting in dysregulated inflammatorystorms” and immunopathology
can occur during pathogenic … /s responsible for exuberant inflammatory responses. Studies …

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

M Soy, G Keser, P Atagündüz, F Tabak… - Clinical …, 2020 - Springer
… Additionally, CD8 T cells harbor high concentrations of cytotoxic granules; … T lymphocytes
recovers in 2–3 months, whereas it may take nearly a year for the memory CD4 T lymphocytes

Constitutive inflammatory cytokine storm: a major threat to human health

KK Gupta, MA Khan, SK Singh - Journal of Interferon & Cytokine …, 2020 - liebertpub.com
pathogens, but excessive inflammation due to an unchecked … T cells results in quick
onset of CRS. IL-6 plays a pivotal role in CRS owing to its pleiotropic property with anti-inflammatory

Autoinflammatory diseases and cytokine storms—imbalances of innate and adaptative immunity

A Marcuzzi, E Melloni, G Zauli, A Romani… - International Journal of …, 2021 - mdpi.com
… in the pathogenesis of atherosclerosis [13]: the T-mediated … effector T cells and Treg cells,
and the effects of these cells lead … Both cell types play a central role in inflammation associated …

[HTML][HTML] Weathering the storm: harnessing the resolution of inflammation to limit COVID-19 pathogenesis

E Silberberg, JG Filep, A Ariel - Frontiers in Immunology, 2022 - frontiersin.org
… M2c macrophages produce CCL16 and CCL18, which consequently promote recruitment
of eosinophils and naive T cells, respectively (29). M2c macrophages are associated with …

Cytokine storms in infectious diseases

JR Teijaro - Seminars in immunopathology, 2017 - Springer
… Specifically, Channappanavar and Perlman highlight how pathogenic CoV … inflammatory
environment marked by elevated cytokines/chemokines and accumulation of inflammatory

T cell immunobiology and cytokine storm of COVID‐19

XH Luo, Y Zhu, J Mao, RC Du - Scandinavian journal of …, 2021 - Wiley Online Library
inflammatory response may be intertwined with T cell activation that could exacerbate disease
or prolong the infection. Most inflammatory … + T cell recovery and pathogen-specific T cells

Imperfect storm: is interleukin-33 the Achilles heel of COVID-19?

G Zizzo, PL Cohen - The Lancet Rheumatology, 2020 - thelancet.com
cells and locally expanded γδ T cells. In severe COVID-19 cases, the IL-33–ST2 axis might
act to expand the number of pathogenic … of anti-inflammatory or resolving M2-like cells (eg, …