Influenza vaccines: challenges and solutions

K Houser, K Subbarao - Cell host & microbe, 2015 - cell.com
… licensed influenza vaccines are generated in the US, why the biology of influenza poses
vaccine challenges, and vaccine approaches on the horizon that address these challenges. …

Next-generation influenza vaccines: opportunities and challenges

CJ Wei, MC Crank, J Shiver, BS Graham… - Nature reviews Drug …, 2020 - nature.com
… of current seasonal vaccines as well as vaccines in the … from influenza antigen structure
and human immunity. We highlight some of the unique challenges facing the influenza vaccine

Improving influenza vaccines: challenges to effective implementation

F Zhou, MC Trieu, R Davies, RJ Cox - Current opinion in immunology, 2018 - Elsevier
… public confidence in seasonal influenza vaccines. In this review, we will look at both challenges
and incremental steps to improving seasonal influenza vaccines and summarize some …

Computational approaches and challenges to developing universal influenza vaccines

X Qiu, VR Duvvuri, J Bahl - Vaccines, 2019 - mdpi.com
… A major challenge in the design of epitope-based vaccines is to focus immune response …
Epitope grafting or scaffolding, has been proposed as a solution for epitope-based vaccine

Increasing the coverage of influenza vaccination in healthcare workers: review of challenges and solutions

KW To, A Lai, KCK Lee, D Koh, SS Lee - Journal of Hospital Infection, 2016 - Elsevier
… may have led to the heterogeneity of the observed vaccination coverage rates. This review
focuses on the prevalence of influenza vaccine uptake by HCWs in major continents, polices …

Vaccine manufacturing: challenges and solutions

JB Ulmer, U Valley, R Rappuoli - Nature biotechnology, 2006 - nature.com
… The recent influenza vaccine shortages have provided a timely … vaccine without the use
of needles. In 2003, a cold-adapted influenza vaccine (CAIV; FluMist, MedImmune Vaccines) …

Seasonal and pandemic influenza: a 2007 update on challenges and solutions

AS Monto, RJ Whitley - Clinical infectious diseases, 2008 - academic.oup.com
… Encouraging data emerged from a phase I study of inactivated split influenza A/Vietnam/1194/2004
(H5N1) vaccine formulations given as 3 doses of hemagglutinin (7.5, 15, and 30 μg) …

Monitoring receipt of seasonal influenza vaccines with BRFSS and NHIS data: challenges and solutions

AE Burger, EN Reither - Vaccine, 2014 - Elsevier
… trends, including influenza vaccination. However, due to limitations in the question that
measures influenza vaccination status, difficulties arise in estimating seasonal vaccination rates. …

Continuing challenges in influenza

RG Webster, EA Govorkova - Annals of the New York Academy …, 2014 - Wiley Online Library
… pathogenic avian H5N1 influenza. Here, we review the challenges facing influenza scientists
and … of achieving the ultimate goal of controlling influenza's ability to change its antigenicity. …

Challenges in the development of egg-independent vaccines for influenza

CM Trombetta, S Marchi, I Manini… - … Review of Vaccines, 2019 - Taylor & Francis
… Introduction: Current influenza vaccines are mainly produced from viruses propagated in …
of influenza vaccine production, starting from egg-based technology, to cell-derived vaccines, …