… is associated with uncontrolled cytokine release, known as a cytokine storm, through JAK/STAT
signaling pathways. Here, we review the FDA-approved JAK inhibitors that are being …

… , STAT3 also is known to contribute to the cytokine storm via … Through the IL-6 and IL-23
signaling, STAT 3 facilitates the … STAT3 activation via JAK2 and therefore the JAK2 inhibitors …

… targeted JAK2/STAT signaling to inhibit CS, we compared the efficacy of JAK-STAT pathway
inhibitors, including the JAK2 inhibitor fedratinib (Fed) and the STAT1 inhibitor fludarabine (…

… result from a cytokine release syndrome or “cytokine storm”, … Of note, while few STAT3 direct
inhibitors are FDA approved, … These efforts might benefit from specific JAK2 inhibitors with …

… JAK2 which in turn activate STAT1, whereas IL-6 can signal via JAK1, JAK2, and/or TYK2
and activates STAT3. … It seems that using a JAK1/JAK2 inhibitor to treat a viral disease might …

… This hyper-inflammatory state produces oxidative stress that … /JAK2 inhibitor licensed to
treat rheumatoid arthritis (RA) that may block viral entry into pneumocytes, prevent cytokine storm…

… Therefore, the treatment of cytokine storm has been … JAK inhibition, therefore, presents an
attractive therapeutic strategy for … This small family consists of JAK1, JAK2, JAK3, and tyrosine …

… Anti-IL6 antibody administration is supported by data showing that a cytokine storm mimicking
sepsis occurs during the course of this viral infection [1]. Further supporting the role of IL6 …

… inhibitor of JAK1 and JAK2 that has been explored in small studies of patients with COVID-19–associated
cytokine storm. … that its inhibition could mitigate the hyperinflammatory state …

… by cytokine storm and hyperinflammatory condition, the state more often leads to … 1, Jak-2,
Jak-3, and Tyk2 seem to be good targets for inhibition by medications to control cytokine storm …