Effects of the SGLT‐2 inhibitor dapagliflozin on glomerular and tubular injury markers

CCJ Dekkers, S Petrykiv, GD Laverman… - Diabetes, Obesity …, 2018 - Wiley Online Library
… 2 inhibition on tubular injury markers. Our data demonstrate that dapagliflozin does not increase
tubular injury markers… kidney injury markers indicates that 6-weeks dapagliflozin therapy …

[PDF][PDF] Effects of dapagliflozin on endothelial function, renal injury markers, and glycemic control in drug-naïve patients with type 2 diabetes mellitus

SH Kong, BK Koo, MK Moon - Diabetes & Metabolism …, 2019 - synapse.koreamed.org
… is an early marker for acute kidney injury … a marker for drug-induced renal injury. One report
indicated that urine NAG increased after sergliflozin treatment, which is an SGLT2 inhibitor

Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury

YK Chang, H Choi, JY Jeong, KR Na, KW Lee, BJ Lim… - PloS one, 2016 - journals.plos.org
… We evaluated whether dapagliflozin reduces renal damage in IR mice model. In addition, …
In conclusion, dapagliflozin attenuates renal IR injury. HIF1 induction by dapagliflozin may …

Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts

TM Lee, NC Chang, SZ Lin - Free Radical Biology and Medicine, 2017 - Elsevier
… and accentuate inflammation after tissue injury, but they are … dapagliflozin or phlorizin
administration leads to inhibitory responses on M1 markers and stimulatory effects on M2 markers

Dapagliflozin, a sodium‐glucose co‐transporter‐2 inhibitor, slows the progression of renal complications through the suppression of renal inflammation, endoplasmic …

K Jaikumkao, A Pongchaidecha… - Diabetes, Obesity …, 2018 - Wiley Online Library
… that dapagliflozin treatment to ameliorate renal injury was … expression of NGAL, a renal injury
marker, and TGF-β1 and … , the improved renal injury observed in the HFD-fed, dapagliflozin-…

Response: Effects of Dapagliflozin on Endothelial Function, Renal Injury Markers, and Glycemic Control in Drug-Naïve Patients with Type 2 Diabetes Mellitus …

SH Kong, BK Koo, MK Moon - Diabetes & Metabolism …, 2019 - synapse.koreamed.org
… The SGLT2 inhibitor dapagliflozin significantly improves the peripheral microvascular
endothelial function in patients with uncontrolled type 2 diabetes mellitus. Intern Med 2018;57:2147…

[HTML][HTML] SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy

P Cassis, M Locatelli, D Cerullo, D Corna, S Buelli… - JCI insight, 2018 - ncbi.nlm.nih.gov
… in the number of podocytes labeled for the specific marker Wilms’ tumor 1 (WT1) was found,
… conditions, suggested that stress/injury modulated the activity of glucose transporters other …

Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells

N Zaibi, P Li, SZ Xu - PLoS One, 2021 - journals.plos.org
… at 0.1 to 5 μM shows a significant protective effect against oxidative stress-induced cell injury.
Both H 2 O 2 -induced apoptosis and cell growth inhibition are alleviated by dapagliflozin. …

Dapagliflozin attenuates contrast-induced acute kidney injury by regulating the HIF-1α/HE4/NF-κB pathway

X Huang, X Guo, G Yan, Y Zhang, Y Yao… - Journal of …, 2022 - journals.lww.com
… In our study, dapagliflozin had an inhibitory effect on the upstream protein HIF-1α and …
expression of NF-κB and caspase-3, which is a marker of cellular apoptosis. We also found that …

Dapagliflozin prevents ERK activation and SGLT2‐dependent endoglin upregulation in a mechanically provoked cardiac injury model

TC Yeh, YC Wu, TY Wong, GC Sun… - Physiological …, 2024 - Wiley Online Library
… (b) Dapagliflozin (DAPA), the inhibitor having higher affinity for SGLT2, is able to prevent
the characteristics of the mechanically provoked biomarkers for cardiac injury. As a result, …