… injury, which involves release of debris and toxic proteins that need to be cleared from
the brain. In a cross-sectional observational study, we estimated glymphatic clearance … -injured …

… This review focuses on the association between the brain-based paravascular drainage
pathway known as the “glymphatic system” and TBI-related neurodegeneration. The …

… The glymphatic system is a waste clearance pathway in the brain. The cerebrospinal fluid
(CSF) enters the brain through the arterial perivascular space, then flows into the brain …

… We next quantified the efficiency by which these manipulations reduced glymphatic clearance
by conventional radiolabeled intracortical injections. The tracers, 3 H-dextran (40 kDa) …

… RmTBI that correlate with injury severity and promote neurodegeneration 13,… glymphatic
clearance function and incite accumulation of phosphorylated tau 5 , suggesting that glymphatic …

… clearance, such as brain injury severity or type of injury … acetazolamide, and CSF drainage
speed was constant in … , which in theory could affect glymphatic clearance, but how this may …

… in glymphatic solute clearance is an underestimate of the impairment occurring after traumatic
injury … and Aqp4 −/− mice are likely not the result of differences in traumatic injury severity. …

… , the patient generally recovers his neurological function, while a severe injury causes a …
[43] studied glymphatic clearance using contrast MRI in mouse models after a mild TBI in vivo. …

… We also assessed glymphatic function 6 months after the head injury, which revealed a
persistent reduction relative to that of age-matched controls (Fig. 2d (right) and Extended Data Fig…

… higher risk factors for insomnia than injury severity [95]. A third … , as impairment of glymphatic
clearance of perivascular … sleep disruption reduces overall glymphatic clearance of these …