Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
… -2 to induce innate immune activation and the contribution of this innate immune signaling
in … In addition, we provide a conceptual framework for innate immunity driving cytokine storm

Coronaviruses: innate immunity, inflammasome activation, inflammatory cell death, and cytokines

SJ Lee, R Channappanavar, TD Kanneganti - Trends in immunology, 2020 - cell.com
… for understanding pathogenesis and innate immunity against SARS-CoV-2 . In this … innate
immune responses, inflammasome activation, inflammatory cell death pathways, and cytokine

Autoinflammatory diseases and cytokine storms—imbalances of innate and adaptative immunity

A Marcuzzi, E Melloni, G Zauli, A Romani… - International Journal of …, 2021 - mdpi.com
… The condition of hyperactivity of innate immunity usually … This double effect is possible
because innate immunity cells … to determine a condition of hyperactivity of innate immunity. …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
… loop between cytokine release and cell death pathways; certain cytokines, pathogen-… to
further cytokine secretion. Here, we discuss recent progress in innate immunity and inflammatory …

Role of the innate cytokine storm induced by the influenza A virus

Y Gu, ACY Hsu, Z Pang, H Pan, X Zuo, G Wang… - Viral …, 2019 - liebertpub.com
innate immune cytokine storms caused by the infection of two common subtypes of IAV. The
innate immune … may be affected by the relevant immune pathology, which may result in even …

Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection

JR Teijaro, KB Walsh, S Rice… - Proceedings of the …, 2014 - National Acad Sciences
… designing of novel therapeutic targets to blunt cytokine storm. Because of the redundant
signaling pathways that generate innate immune responses, we anticipate effective therapy will …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
innate immune cells, resulting in cytokine storms. Collectively, the impaired acquired immune
responses and uncontrolled inflammatory innate … SARS-CoV-2 may cause cytokine storms. …

Controlling cytokine storm is vital in COVID-19

L Tang, Z Yin, Y Hu, H Mei - Frontiers in immunology, 2020 - frontiersin.org
… This review will summarize advances in the research of cytokine storms induced by COVID-19…
of innate immunity may be an important factor in the formation of cytokine storms in COVID-…

Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19

RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
… to cytokine storm, … cytokines and the cellular components of the innate immune system,
which can aid in viral clearance but also contribute to inflammatory cell death, cytokine storm, and …

Innate immunity: the first line of defense against SARS-CoV-2

MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
… damage, cytokine storm and acute respiratory distress syndrome. The innate immune system
… Here, we discuss innate immune processes involved in SARS-CoV-2 recognition and the …