Chronic kidney disease, basal insulin glargine, and health outcomes in people with dysglycemia: the ORIGIN Study

V Papademetriou, ES Nylen, M Doumas… - The American journal of …, 2017 - Elsevier
… had a neutral effect on cardiovascular outcomes.10, 11 In … kidney disease and of insulin
glargine, in people with and without early chronic kidney disease, on cardiovascular outcomes in …

Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 …

HJL Heerspink, N Sattar, I Pavo, A Haupt… - The Lancet Diabetes & …, 2022 - thelancet.com
… of tirzepatide and insulin glargine on kidney parameters and outcomes in people … of kidney
outcomes, with a low risk of clinically relevant hypoglycaemia, compared with insulin glargine

Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised …

KR Tuttle, MC Lakshmanan, B Rayner… - The lancet Diabetes & …, 2018 - thelancet.com
… Studies including prespecified kidney outcome data were identified. Composite kidney
outcomes were reported in a prespecified analysis of the LEADER cardiovascular outcome trial, …

Clinical outcomes by albuminuria status with dulaglutide versus insulin glargine in participants with diabetes and CKD: AWARD-7 exploratory analysis

KR Tuttle, B Rayner, MC Lakshmanan, AYM Kwan… - Kidney360, 2021 - journals.lww.com
… with the composite kidney outcome in participants with … kidney outcome in participants
with baseline microalbuminuria. (C) Proportion of participants with the composite outcome in …

Basal insulin glargine and microvascular outcomes in dysglycaemic individuals: results of the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial

ORIGIN Trial Investigators, RE Gilbert, JFE Mann… - Diabetologia, 2014 - Springer
… Allocation to the insulin glargine group reduced the incidence of the primary microvascular
composite outcome of kidney and eye disease in participants whose baseline HbA 1c level …

Insulin glargine U100 improved glycemic control and reduced nocturnal hypoglycemia in patients with type 2 diabetes mellitus and chronic kidney disease stages 3 …

CC Betônico, SMO Titan, A Lira, TS Pelaes… - Clinical …, 2019 - Elsevier
… Our results found that insulin glargine U100 could be effective, … episodes compared with
NPH insulin in this population. These … outcomes of insulin glargine with NPH insulin, premixed …

[HTML][HTML] A retrospective observational study of insulin glargine in type 2 diabetic patients with advanced chronic kidney disease

A Majumder, S RoyChaudhuri, D Sanyal - Cureus, 2019 - ncbi.nlm.nih.gov
renal function, or on drugs that may adversely affect renal … short-acting regular human insulin,
received insulin glargine as the … In the outcome reduction with initial glargine intervention (…

Comparative effects of glucose-lowering medications on kidney outcomes in type 2 diabetes: the GRADE randomized clinical trial

DJ Wexler, IH De Boer, A Ghosh, N Younes… - JAMA internal …, 2023 - jamanetwork.com
… , the sulfonylurea glimepiride, the GLP-1 receptor agonist liraglutide, and the basal insulin
glargine. As noted, DPP-4 inhibitors and GLP-1 receptor agonists have shown modest …

Long-term insulin glargine therapy in type 2 diabetes mellitus: a focus on cardiovascular outcomes

JJ Joseph, TW Donner - Vascular health and risk management, 2015 - Taylor & Francis
… controlled in DCCT, sustained reductions in nephropathy, neuropathy, and retinopathy
were observed, in addition to reductions in severe retinal and renal outcomes. Citation57 …

[PDF][PDF] Efficacy and safety of insulin glargine in type 2 diabetic patients with renal failure

M Niafar, M Nakhjavani, A Esteghamati, A Ziaee… - J Diabetes …, 2012 - researchgate.net
… the safety and efficacy of insulin glargine in type 2 diabetic … the safety and efficacy of insulin
glargine in type 2 diabetic … (OAD) or NPH insulin received insulin glargine at bedtime. The …