… Here, we report a systems-level study of disease-associated proteome changes in human
… an integrated approach that combines mass spectrometry-based quantitative proteomics, …

… Here, we used integrative proteomics to identify cerebrospinal fluid (CSF) biomarkers …
proteome resolved 44 biologically diverse modules, 15 of which overlapped with the CSF proteome…

Many disease processes in the brain are reflected in the protein composition of the cerebrospinal
fluid (CSF). In addition to proteins, CSF also contains a large number of endogenous …

… ) of cultured neurons and integrated the results with the AD brain … the utility of integrating the
proteome from the human brain … Alzheimer's disease brain reveals strong proteomic disease-…

… Our study highlights that the interpretation of multi-omics data such as lipidomics, proteomics
and genomics can be boosted by deploying systems biology approaches. Our integrative …

… complex diseases like Alzheimer's disease. We constructed a “Core” Alzheimer's disease …
protein interaction network yet constructed for Alzheimer's disease. An “Expanded” network …

Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We
characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 …

… In brief, a total of 10 individual datasets from three independent deep proteomic studies
were integrated for this analysis. The ranks of proteins were normalized by the total number of …

… disease may boost sensitivity and help prevent mistakes when comparing CSF fluid and plasma
for disease biomarker discovery by proteomics and … of the proteome results from multiple …

There is an urgent need to identify biomarkers for Alzheimer’s disease (AD), but the identification
of reliable blood-based biomarkers has proven to be much more difficult than initially …