COVID-19 drug discovery using intensive approaches

A Asai, M Konno, M Ozaki, C Otsuka… - International journal of …, 2020 - mdpi.com
… workers to treat COVID-19 using previously approved or investigational drugs [2]. Here,
we gathered information that may be pertinent to drug discovery for COVID-19 via a systemic …

A critical overview of computational approaches employed for COVID-19 drug discovery

EN Muratov, R Amaro, CH Andrade, N Brown… - Chemical Society …, 2021 - pubs.rsc.org
… Clearly, an immediate emergence of new, effective drugs for COVID-19 has not been an
option because the usual extensive drug development and clinical testing takes 10–15 years. …

[HTML][HTML] COVID-19 drug development

S Kim - Journal of microbiology and biotechnology, 2022 - ncbi.nlm.nih.gov
… agent of COVID-19. Drug development has been conducted in various ways including …
attention than any of the other drugs and were the targets of intensive investigation early in the …

Genomics insights of SARS-CoV-2 (COVID-19) into target-based drug discovery

P Chellapandi, S Saranya - Medicinal Chemistry Research, 2020 - Springer
Intensive research on SARS-CoV-2 is urgently warranted to understand its pathogenesis …
are discussed intensively. Several molecular docking and systems pharmacology approaches

COVID-19: molecular targets, drug repurposing and new avenues for drug discovery

MR Senger, TCS Evangelista, RF Dantas… - Memórias do Instituto …, 2020 - SciELO Brasil
SciELO - Brasil - COVID-19: molecular targets, drug repurposing and new avenues for drug
discovery COVID-19: molecular targets, drug repurposing and new avenues for drug

Challenges of drug development during the COVID19 pandemic: key considerations for clinical trial designs

J Shi, Y Xiao, Y Zhang, D Geng, D Cong… - British Journal of …, 2021 - Wiley Online Library
… trials remain a growing area of interest for reaching methods of controlling COVID-19. …
supplemental oxygen or intensive care and current estimates of COVID-19 case fatality rates vary …

The broad-spectrum antiviral recommendations for drug discovery against COVID-19

A Hazafa, K Ur-Rahman, I Haq, N Jahan… - Drug metabolism …, 2020 - Taylor & Francis
… population against the threat of COVID-19. However, to … approaches for the treatment and
prevention of COVID-19 by … for coronavirus were relatively low after the intensive effort to …

Drug repositioning: new approaches and future prospects for life-debilitating diseases and the COVID-19 pandemic outbreak

ZY Low, IA Farouk, SK Lal - Viruses, 2020 - mdpi.com
extensive research on the chemistry or molecular biology/biochemical formulation. Drug
design … , genomics and combinatorial chemistry, drug discovery has advanced in precision and …

Pandemic drugs at pandemic speed: infrastructure for accelerating COVID-19 drug discovery with hybrid machine learning-and physics-based simulations on high …

AP Bhati, S Wan, D Alfè, AR Clyde, M Bode… - Interface …, 2021 - royalsocietypublishing.org
… unable to explore the extensive chemical space relevant for drug molecule generation. To
… for drug design by coupling ML with PB methods. We bring together several methods into a …

Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - … Reviews Drug Discovery, 2023 - nature.com
… the COVID-19 pandemic has been reflected in the extensive … learned from six decades of
antiviral drug discovery 5,6,7,8 , … b, Fragment crystallizable (Fc)-engineering approaches that …