… By comparing viral infection in wild-type, IFNLR1 0/0 , IFNAR 0/0 and double-knockout mice…
contribution of IFN-λ to the control of viral infection greatly varied according to the virus [13]. …

… IFN-λ receptor IL10R2/IFNLR1 (Table 1) and their genes are clustered on human chromosome
19. Similarly to type I IFN, their inducibility by virus infection appears to be ubiquitous [6]. …

… IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment
of viral infectious … -ω induces a similar amount of IFN-α, IFN-β and IFN-λ mRNA but differs in …

… type 2 (HSV-2), whereas IFN-α potently restricted both viruses. Using three murine models
… virus infections, we found that while recombinant IFN-α reduced the viral load after infection …

… This study describes the dynamics of IFN-β responses to viral infection using lung infection
… other IFN pathways such as IFN-λ could also be effective at modulating viral infections (36–39…

… Type-III interferons (IFN-λ, IFNL) are the most recently … biology of IFNL during viral infection,
and the implications of this … IFNLs exert antiviral effects via induction of IFN-stimulated genes…

… into IFN-λ functions, including its ability to restrict virus spread into the brain and to clear
chronic viral infections in the gastrointestinal tract. We also discuss how IFN-λ modulates innate …

… Here, we analyzed the mechanism by which IFN-λ gene expression is induced by viral
infections. Loss- and gain-of-function experiments revealed the involvement of RIG-I (retinoic acid-…

… Using mice lacking functional receptors for type I IFN, type III IFN, or both, we found that
IFN-λ plays an important role in the defense against several human pathogens that infect the …

… advances regarding IFN-λ-mediated regulation of enteric viruses with … We also briefly discuss
IFN-λ interactions with other … RV infection in enteroids indeed induced IFN-λ and interferon-…