… However, successful viruses like SARS-CoV-2 have evolved strategies to evade or counteract
… overview of how SARS-CoV-2 uses many of its proteins to counteract IFN induction and …

… the key viral interferon antagonists of SARS-CoV-2 and … SARS-CoV-2 interferon antagonists
identified in this study are highlighted orange, with PLpro that has compromised interferon …

… between SARS-CoV and SARS-CoV-2 in 15 viral proteins shown to be interferon antagonist.
… to ORF6 suggest the two key IFN antagonists may not maintain 17 equivalent function in …

… Because the ORF3b length is remarkably different between SARS-CoV-2 and SARS-CoV
(Figure 1B), we hypothesized that the antagonistic activity of ORF3b against IFN-I also differs …

… IFN antagonistic proteins summarized in this review. Identification of natural SARS-CoV-2
variants with the potential IFN antagonists mutated also could be valuable to assess the IFN-…

… To evaluate the antagonistic function of SARS-CoV-2 protein 6 in interferon signalling,
we did single-cycle infection experiments (MOI of 1) in Vero E6 cells. We allowed for 16 h of …

… Comparing SARS-CoV-2 and influenza A virus in human … observe the absence of IFN-I
stimulation by SARS-CoV-2 alone … of IFN-I antagonist proteins encoded by SARS-CoV-2, SARS-…

… IFN antagonist proteins within the SARS-CoV genome [80, 83]. Structural components of the
SARS-CoV virion acting as antagonists of IFN … antagonism of IFN signaling by SARS-CoV is …

… SARS-CoV-2 induces overt but delayed type-I interferon (IFN) responses. By screening 23
viral proteins, we find that SARS-CoV-… of SARS-CoV ORF6 is critical for its antagonistic activity …

… -2 ORF6, ORF8, N and ORF3b are potent interferon antagonist, in the early stages of
SARS-CoV-2 infection, delayed release of IFNs would hinder the host's antiviral response and then …