… expression by IFN-γ is mediated by IRF-1 and IRF-2. Previously, we have identified an
IRF-… We next investigated whether the IL-4 IRF sites interact with IRFs induced by IFN-γ in …

… Additionally, IFN-γ activated autophagy in … that IFN-γ induces autophagy through IRF-1
signaling pathway and the induction of autophagy contributes to the growth-inhibitory effect of IFN-…

… of IRF-1–dependent activation 7,8,40. We took advantage of mice with targeted disruptions
in IRF-1 or IRF-2 genes for the analysis of the expression of Cox-2 after treatment with IFN-γ …

… -γ to its cell surface receptor, which consists of two subunits IFNGRs (interferon gamma
receptors)-1 and -2, and each molecule interacts with a member of the JAK family, which are non-…

… -1 gene, NFγB and IRF-1 boxes. By making deletions of the promoter, we found that only the
proximal GAS and IRF-1 boxes are required for IFN-γ induction of Tap-1 … 30 min with IFN-γ …

… IFN-γ inhibits erythropoiesis by activation of an IRF-1-PU.1 axis. Because type I IFNs can also
induce expression of IRF-1 … we expect that chronic production of IFN-α or IFN-β can elicit a …

… IRF-1 transcription factor. RANTES promoters with mutations in the NF-κB or IRF binding sites
were not stimulated by p65 or IRF1 … that IRF-1 was induced after cells were treated with IFN…

… Thus, we hypothesized that IRF-1 may directly mediate the enhancer effects of IFN-γ in
TRAIL-… IRF-1 by taking advantage of AdIRF-1, an adenoviral vector expressing IRF-1. AdIRF-…

… We report here that interferon regulatory factor 1 (IRF-1) is an essential molecule in these
phenomena. Hepatocytes from IRF-1-deficient mice were completely resistant to IFN- in …

… that IRF-1 is one of the newly synthesized proteins involved in iNOS expression. Besides the
putative effects of IFN-… In the present study, we examined IFN-γ actions on NF-κB and IRF-1 …