P Li, Q Du, Z Cao, Z Guo, J Evankovich, W Yan… - Cancer letters, 2012 - Elsevier
… Additionally, IFN-γ activated autophagy in … that IFN-γ induces autophagy through IRF-1 signaling pathway and the induction of autophagy contributes to the growth-inhibitory effect of IFN-…
JCG Blanco, C Contursi, CA Salkowski… - The Journal of …, 2000 - rupress.org
… of IRF-1–dependent activation 7,8,40. We took advantage of mice with targeted disruptions in IRF-1 or IRF-2 genes for the analysis of the expression of Cox-2 after treatment with IFN-γ …
D Murtas, D Maric, V De Giorgi, J Reinboth… - British journal of …, 2013 - nature.com
… -γ to its cell surface receptor, which consists of two subunits IFNGRs (interferongamma receptors)-1 and -2, and each molecule interacts with a member of the JAK family, which are non-…
… -1 gene, NFγB and IRF-1 boxes. By making deletions of the promoter, we found that only the proximal GAS and IRF-1 boxes are required for IFN-γ induction of Tap-1 … 30 min with IFN-γ …
SF Libregts, L Gutiérrez, AM de Bruin… - Blood, The Journal …, 2011 - ashpublications.org
… IFN-γ inhibits erythropoiesis by activation of an IRF-1-PU.1 axis. Because type I IFNs can also induce expression of IRF-1 … we expect that chronic production of IFN-α or IFN-β can elicit a …
… IRF-1 transcription factor. RANTES promoters with mutations in the NF-κB or IRF binding sites were not stimulated by p65 or IRF1 … that IRF-1 was induced after cells were treated with IFN…
SY Park, JW Seol, YJ Lee, JH Cho… - European journal of …, 2004 - Wiley Online Library
… Thus, we hypothesized that IRF-1 may directly mediate the enhancer effects of IFN-γ in TRAIL-… IRF-1 by taking advantage of AdIRF-1, an adenoviral vector expressing IRF-1. AdIRF-…
A Kano, T Haruyama, T Akaike, Y Watanabe - Biochemical and biophysical …, 1999 - Elsevier
… We report here that interferon regulatory factor 1 (IRF-1) is an essential molecule in these phenomena. Hepatocytes from IRF-1-deficient mice were completely resistant to IFN- in …
M Flodström, DL Eizirik - Endocrinology, 1997 - academic.oup.com
… that IRF-1 is one of the newly synthesized proteins involved in iNOS expression. Besides the putative effects of IFN-… In the present study, we examined IFN-γ actions on NF-κB and IRF-1 …