Interferon lambdas: the next cytokine storm

C Kelly, P Klenerman, E Barnes - Gut, 2011 - gut.bmj.com
… Recently, several large genome-wide association studies have identified single nucleotide
polymorphisms (SNPs) linked to interferon lambda 3 (IFNλ3) that are associated with the …

COVID‐19: lambda interferon against viral load and hyperinflammation

E Andreakos, S Tsiodras - EMBO molecular medicine, 2020 - embopress.org
… system that triggers the infiltration of immune cells such as neutrophils and macrophages
into the lung along with a “cytokine storm”—the excessive or uncontrolled production of …

Linkage of lambda interferons in protection against severe COVID-19

M Shahbazi, P Amri Maleh, M Bagherzadeh… - … Interferon & Cytokine …, 2021 - liebertpub.com
… Therefore, we aimed to evaluate the serum levels of IFN-λ1 and IFN-λ2 in intensive care unit
IFN-λs might be an optional treatment for COVID-19 patients by inhibiting the cytokine storm

The key roles of interferon lambda in human molecular defense against respiratory viral infections

AA Lozhkov, SA Klotchenko, ES Ramsay, HD Moshkoff… - Pathogens, 2020 - mdpi.com
… of an uncontrolled pro-inflammatory response, or “cytokine storm” [108], which is one of
the … ) and to the development of a “cytokine storm” hiding the protective effects of IFN-λ [113]. …

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

P Laurent, C Yang, AF Rendeiro… - Science …, 2022 - science.org
IFN-I signature, with the cytokine storm in macrophages. We observed that pDCs were the
dominant IFN-… virus in the blood, whereas macrophages produced IFN-α only when in physical …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
… a cytokine storm and the biological consequences of cytokine overproduction. We will also
look at the cytokine stormLambda IFNs are a new class of IFN with antiviral properties (127), …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
… cell sources of cytokines associated with cytokine storms; IFN-γ, TNF-α, IL-1 and IL-6 are …
, receptor complex IL-28R/IL-10Rβ for type III—also known as lambda interferons), interferons

Cytokine storm in COVID-19 and the treatment simulacrum

A Karimi, SMR Hashemian - Biomedical and Biotechnology …, 2020 - journals.lww.com
… There are ongoing studies, but the term “cytokine storm” can be a possible clue of the … of
molecular and cellular pathways of cytokine storms and also discuss some recent trials of the …

Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium

YG Liu, SW Jin, SS Zhang, TJ Xia, YH Liao… - Frontiers in …, 2024 - frontiersin.org
… of inflammatory cytokines, which results in the development of an inflammatory cytokine storm
cytokines to avoid cytokine storms. Nonetheless, recent studies remind us that when using …

Alterations in the expression of IFN lambda, IFN gamma and toll-like receptors in severe COVID-19 patients

L Sorrentino, M Fracella, F Frasca, A D'Auria… - Microorganisms, 2023 - mdpi.com
… Contradictory results have been reported regarding interferon (IFN) lambda (λ1–3) and IFN
… Analyzing Toll-like receptors (TLRs) involved in IFN production, we found that TLR3 was …