… On the other hand, IL-1 alpha is found constitutively produced by various epithelial cells,
keratinocytes of the skin and in the brain. In these locations, IL-1 may contribute to cell growth …

… interleukin-1 family consists of three structurally related polypeptides. The first two are
interleukin-1α and interleukin-1β… is interleukin-1-receptor antagonist, which inhibits the activities of …

… ble evolution from a reverse transcribed prointerleukin-1 alpha gene. Nucleic Acids Res 14:…
sequence of the gene for human interleukin-l-alpha. Nucleic Acids Res 14:3167-3179, 1986 …

… It was given the unifying term interleukin 1 in 1979. … The third is the interleukin 1 receptor
antagonist protein (IRAP). All share 20–25% amino acid homology. Mature IL1α and β have …

… interleukin 1 (IL-1) by human peripheral blood monocytes. Polyclonal antisera generated
against either recombinant IL-1 alpha (p15) or IL-1 … results, no processed IL-1 (alpha or beta) is …

… IL 1 precursor (IL 1 beta). We have expressed the carboxy-terminal 154 amino acids of IL 1
alpha … IL 1 in several different IL 1 assays based on murine and human cells. Recombinant IL …

… coli-derived recombinant murine interleukin 1 alpha (IL 1 alpha) was labeled with 125I
and used for receptor binding studies. The 125I-IL 1 binds to murine EL-4 thymoma cells in a …

… The interleukin 1 (IL-1) family of proteins has a central role in modulating immune and
inflammatory responses. Two major IL-1 proteins, designated a (IL-la) and /3 (IL-1/3), are …

Both IL-1 alpha and IL-1 beta are initially translated as approximately Mr 30,000 polypeptides
and processed to approximately Mr 17,500 prior to, or during, release from macrophages. …

… Dinarello CA, Ikejima T., Warner SJ, Orencole SF, Lonnemann G., Cannon JG, Libby P.,
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in …