Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

… IL-1 is active in the low pM and fM range and IL-1 receptors (IL-1R) are expressed … -1
receptors in humans and animals and IL-1 beta knock-out mice, there is no evidence that IL-1 beta …

… , a cysteine protease responsible for the activation of pro-interleukin-l… Interleukin 1 is processed
and released during apop- … Human interleukin 1 is a cytocidal factor for several tumor cell …

… Bovine brainderived acidic and basic fibroblast growth factors have significant amino acid
homologies with IL-1beta and, to a lesser degree, with IL-l-alpha (30). From a structural point …

… It was given the unifying term interleukin 1 in 1979. … The third is the interleukin 1 receptor
antagonist protein (IRAP). All share 20–25% amino acid homology. Mature IL1α and β have …

Interleukin-1 beta is a proinflammatory cytokine produced by blood-borne and resident
brain inflammatory cells. The present study was conducted to determine if interleukin-1 beta …

… IL 1 alpha and IL 1 beta to compete for binding of the radiolabeled murine IL 1 to its receptor
and to stimulate IL 2 production by EL-4 cells. Previous reports have shown that human IL 1 …

… Dinarello CA, Ikejima T., Warner SJ, Orencole SF, Lonnemann G., Cannon JG, Libby P.,
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in …

… ABSTRACT Interleukin 1 (IL-1) is a lymphokine secreted by monocytes in response to a
variety of inflammatory stimuli. IL-1fB the predominant form of IL-1 produced by human …

… precursor interleukin 1 beta (IL1 beta) by elastase, cathepsin G, and collagenase, the major
proteases released at sites of inflammation, was investigated using recombinant pro-IL1 beta…