Interleukin-1 in COVID-19 Infection: Immunopathogenesis and Possible Therapeutic Perspective

A Mardi, S Meidaninikjeh, S Nikfarjam… - Viral …, 2021 - liebertpub.com
… In addition, the IL-1 cytokine family has a pivotal role in the induction of cytokine storm due
COVID-19 infection. This article reviews the role of IL-1 in inflammation and utilization of IL-1

Interleukin1 blocking agents for treating COVID19

Cochrane Emergency and Critical Care … - Cochrane Database …, 1996 - cochranelibrary.com
… ‐1 blocking agents compared with standard care alone or with placebo on effectiveness and
safety outcomes in people with COVID19. … on the COVID‐NMA platform ( covid-nma.com) . …

NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis

N Potere, E Garrad, Y Kanthi, M Di Nisio… - Cardiovascular …, 2023 - academic.oup.com
… We herein outline the contribution of immunothrombosis to COVID-19-… of COVID-19. We
also summarize current efforts to target the NLRP3 inflammasome pathway in COVID-19, and …

Interleukin-1 and interleukin-6 inhibition compared with standard management in patients with COVID-19 and hyperinflammation: a cohort study

G Cavalli, A Larcher, A Tomelleri… - The Lancet …, 2021 - thelancet.com
… differences in global outcomes of COVID-19 patients treated with IL-1 versus IL-6 … COVID-19
as well as the design of controlled investigations evaluating cytokine inhibitors in COVID-19

Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study

G Cavalli, G De Luca, C Campochiaro… - The Lancet …, 2020 - thelancet.com
… Mortality of patients with coronavirus disease 2019 (COVID-19), … Anakinra is a recombinant
interleukin-1 receptor antagonist … This study is part of the COVID-19 Biobank study, which is …

[HTML][HTML] Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

N Potere, MG Del Buono, R Caricchio, PC Cremer… - …, 2022 - thelancet.com
coronavirus 2 (SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus
disease 2019 (COVID-19… Evidence suggests that inflammasome activation and interleukin-1β (IL…

[HTML][HTML] Specific interleukin-1 inhibitors, specific interleukin-6 inhibitors, and GM-CSF blockades for COVID-19 (at the edge of sepsis): a systematic review

Y Wang, K Zhu, R Dai, R Li, M Li, X Lv… - Frontiers in …, 2022 - frontiersin.org
… ), some severe and critically ill COVID-19 patients with multiple organ … specific interleukin
(IL)-1 inhibitors, specific IL-6 inhibitors, and GM-CSF blockades in the treatment of COVID-19 (…

[HTML][HTML] Genetic variation of interleukin-1 receptor type 1 is associated with severity of COVID-19 disease

R Wang - The Journal of Infection, 2022 - ncbi.nlm.nih.gov
… IL-1 family are central mediators of the COVID-19 cytokine storm. Thus, we aim to explore
whether a genetic variation of the IL-1 family is associated with COVID-19. The acronym IL-1

[HTML][HTML] Interleukin1 blockade with anakinra in acute leukaemia patients with severe COVID19 pneumonia appears safe and may result in clinical improvement

JW Day, TA Fox, R Halsey, B Carpenter… - British Journal of …, 2020 - ncbi.nlm.nih.gov
… by coronavirus disease 2019 (COVID19) worldwide has exceeded 4·5 million. A subgroup
of patients with COVID19COVID19 and are currently being investigated in clinical trials. …

[HTML][HTML] The safety and efficacy of anakinra, an interleukin-1 antagonist in severe cases of COVID-19: a systematic review and meta-analysis

MKR Somagutta, MKL Pormento, P Hamid… - Infection & …, 2021 - ncbi.nlm.nih.gov
… safety and efficacy for treating severe coronavirus disease 2019 (COVID-19). Numerous
electronic … Anakinra is beneficial in lowering mortality in COVID-19 patients. However, these non-…