Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue … of
cytokine storms. In this review, we present the current understanding of the diverse roles of IL-6, its …

[HTML][HTML] Cytokine storm with rapidly elevated interleukin-6 indicates sudden death in patients with critical COVID-19

Z Hu, S Li, X Song - Cytokine & growth factor reviews, 2021 - ncbi.nlm.nih.gov
… that cytokine storm manifested by rapidly elevated IL-6 in a short time maybe the main cause
of sudden death. All 8 patients with cytokine storm … long-term cytokine storm. We performed …

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
… controversies and demonstrate that cytokine storm syndrome may play … cytokine storm
syndrome Critics of the COVID-CSS concept have claimed that “cytokine storm has no definition” [6

Interleukin-6 perpetrator of the COVID-19 cytokine storm

J Shekhawat, K Gauba, S Gupta, P Purohit… - Indian Journal of Clinical …, 2021 - Springer
… by Cytokine Storm (CS). CS is marked by elevated levels of inflammatory cytokines, mainly
interleukin-6 (IL-6), … Of these, IL-6 is found to be significantly associated with higher mortality. …

Immunotherapeutic implications of IL-6 blockade for cytokine storm

T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Taylor & Francis
… ‘cytokine storm’. This review focuses on the pathological role of IL-6 in a cytokine storm and
the therapeutic effect of IL-6Interleukin 6 (IL-6) levels in the monitoring of surgical trauma. A …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… to a hyperinflammatory state (“cytokine storm”) followed by acute respiratory … cytokine storm
in its severest form has been marked by elevation of IL-6, IL-10, TNF-α, and other cytokines

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
… The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine
… We propose to utilize interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS and …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… is an urgent need to understand the cytokine storm in COVID‐19. … cytokine storm induced
by COVID‐19. In addition, we suggest that the identification and treatment of the cytokine storm

Interleukin-6, CXCL10 and infiltrating macrophages in COVID-19-related cytokine storm: not one for all but all for one!

F Coperchini, L Chiovato, M Rotondi - Frontiers in immunology, 2021 - frontiersin.org
IL-6 induces a transcriptional inflammatory response through its binding to interleukin 6
receptor, alpha (IL-6Rα) (30). IL-6 is involved in the promotion of the specific differentiation of …

Anti-interleukin-6 monoclonal antibody for cytokine storm in COVID-19

S Douedi, M Chaudhri, J Miskoff - Annals of Thoracic Medicine, 2020 - journals.lww.com
… illness and produce a cytokine storm associated with increased morbidity and … -interleukin-6
receptor monoclonal antibody, has been found to be effective in managing the cytokine storm