Expression, regulation and function of intestinal drug transporters: an update

J Müller, M Keiser, M Drozdzik, S Oswald - Biological chemistry, 2017 - degruyter.com
intestinal drug solubility and intestinal metabolism. One further determinant identified and
characterized during the last two decades is the intestinal drug transportintestinal transporters

Intestinal drug transporters: an overview

M Estudante, JG Morais, G Soveral, LZ Benet - Advanced drug delivery …, 2013 - Elsevier
drugs. This review also discusses BDDCS predictions with respect to the role of intestinal
transporters and intestinal transporter-metabolizing enzyme interplay on oral drug

Intestinal drug transporters in pathological states: An overview

M Drozdzik, I Czekawy, S Oswald, A Drozdzik - Pharmacological Reports, 2020 - Springer
… stands behind more efficient absorption of its substrates in the upper intestine [9]. It is
obvious, that not only intestinal drug transporters are unique determinants of transporter-mediated …

Intestinal drug transporters: in vivo function and clinical importance

JR Kunta, PJ Sinko - Current Drug Metabolism, 2004 - ingentaconnect.com
… of transporters in intestinal drug absorption and secretion, has had a dramatic impact on drug
… Although the role of carrier-mediated intestinal drug transport on oral bioavailability is well …

The biological and clinical role of drug transporters at the intestinal barrier

RL Oostendorp, JH Beijnen, JHM Schellens - Cancer Treatment Reviews, 2009 - Elsevier
… in the disposition of a broad range of drugs, toxins, endogenous compounds and their … ABC
and SLC drug transporters at the intestinal barrier and the impact of these transporters on the …

Hepatic and intestinal drug transporters: prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms

K Yoshida, K Maeda, Y Sugiyama - Annual review of …, 2013 - annualreviews.org
drug transporters on the clinical pharmacokinetics of new drug candidates in the early phase
of drug … of clinically relevant transporter-mediated DDIs (TP-DDIs) and pharmacogenetics of …

Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation

T Katsura, K Inui - Drug metabolism and pharmacokinetics, 2003 - jstage.jst.go.jp
… expression levels of drug transporters seems to be … drug transporters in the small intestine
could be responsible for the intra- and interindividual variability of oral bioavailability of drugs. …

Down-regulation of intestinal drug transporters in chronic renal failure in rats

J Naud, J Michaud, C Boisvert, K Desbiens… - … of Pharmacology and …, 2007 - ASPET
… of CRF on other intestinal drug transporters are unknown. The objectives of this study were
to determine the effects of CRF on some major intestinal drug transporters and to define the …

Intestinal drug transporter expression and the impact of grapefruit juice in humans

H Glaeser, DG Bailey, GK Dresser… - Clinical …, 2007 - Wiley Online Library
intestinal drug transporter expression, determine the subcellular localization of the drug uptake
transporter … Expression of drug uptake and efflux transporters was assessed using human …

Expression and function of efflux drug transporters in the intestine

M Takano, R Yumoto, T Murakami - Pharmacology & therapeutics, 2006 - Elsevier
… activity of efflux transporters exhibit marked … drugs and daily foods and beverages. In
this article, we will summarize the recent findings regarding the intestinal efflux transporters, …