Intranasal antibody prophylaxis for protection against viral disease

R Weltzin, TP Monath - Clinical microbiology reviews, 1999 - Am Soc Microbiol
… In animal studies, RSV infection has been the primary target for therapeutic intranasal passive
immunization. These studies show that intranasal delivery of neutralizing antibody, either …

Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine

A Ainai, S Tamura, T Suzuki, R Ito… - Journal of medical …, 2012 - Wiley Online Library
… In conclusion, intranasal administration of an A/Uruguay split vaccine … nasal and serum
neutralizing antibody responses in four out of five healthy adult subjects, with a neutralization titre …

Direct administration in the respiratory tract improves efficacy of broadly neutralizing anti-influenza virus monoclonal antibodies

VH Leyva-Grado, GS Tan, PE Leon… - Antimicrobial agents …, 2015 - Am Soc Microbiol
… A group of mice received phosphate-buffered saline (PBS) via intranasal administration as
… Here we demonstrate that treatment with a broadly neutralizing MAb via the intranasal or …

[HTML][HTML] Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

S Halwe, A Kupke, K Vanshylla, F Liberta, H Gruell… - Viruses, 2021 - mdpi.com
… used neutralizing antibodiesneutralizing antibody that binds the receptor-binding
domain of the SARS-CoV-2 spike protein. DZIF-10c displays an exceptionally high neutralizing

[HTML][HTML] Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

JQ Li, ZR Zhang, HQ Zhang, YN Zhang… - … and Targeted Therapy, 2021 - nature.com
… RNA expressing SARS-CoV-2 neutralizing mAb through intranasal route. Our results addressed
the … We show that single intranasal administration of VEEV-VRP-CB6 could cause the …

Intranasal administration of a virus like particles‐based vaccine induces neutralizing antibodies against SARS‐CoV‐2 and variants of concern

DA Rothen, PS Krenger, A Nonic, I Balke, ACS Vogt… - Allergy, 2022 - Wiley Online Library
… Our data demonstrate that intranasal administration of CuMV TT -RBD induces a
protective systemic and local specific antibody response against SARS-CoV-2 and its VOCs. …

Intranasal administration of SARS-CoV-2 neutralizing human antibody prevents infection in mice

H Zhang, Z Yang, J Xiang, Z Cui, J Liu, C Liu - BioRxiv, 2020 - biorxiv.org
… Therefore, we explored whether directly deploying SARS-CoV-2 neutralizing antibodies into
… A nasal spray can then be used to deliver SARS-CoV-2 neutralizing antibodies in a simple …

[HTML][HTML] Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants

J Lu, Q Yin, R Pei, Q Zhang, Y Qu, Y Pan, L Sun, D Gao… - Virologica Sinica, 2022 - Elsevier
… -19), the use of broadly neutralizing antibodies has been considered as an alternative way for
… that the nasal delivery of two previously characterized broadly neutralizing antibodies (F61 …

[HTML][HTML] A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

X Zhang, H Zhang, T Li, S Chen, F Luo… - Signal transduction and …, 2022 - nature.com
… of its neutralizing ability against … intranasal administration in a Syrian golden hamster
model against the Delta and Omicron variants. When delivered via the respiratory tract (intranasal

Intranasal delivery of recombinant parvovirus-like particles elicits cytotoxic T-cell and neutralizing antibody responses

C Sedlik, A Dridi, E Deriaud, MF Saron… - Journal of …, 1999 - Am Soc Microbiol
… these pseudoparticles after mucosal administration. This study demonstrates … administered
by the intranasal route, in the absence of adjuvant, induced specific IgG and/or IgA antibodies