Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management

VP Chavda, LK Vora, AK Pandya, VB Patravale - Drug discovery today, 2021 - Elsevier
… S-protein that can prevent SARS-CoV-2 infection and pneumonia in mice. Single intranasal
administration of the vaccine was studied in a stringent SARS-CoV-2 challenge model in …

Intranasal administration of a recombinant RBD vaccine induced protective immunity against SARS-CoV-2 in mouse

Y Du, Y Xu, J Feng, L Hu, Y Zhang, B Zhang, W Guo… - Vaccine, 2021 - Elsevier
… full-length SARS-CoV-2 protein administered via intranasal … immunogenicity of an intranasal
immunized SARS-CoV-2 … immunized with a recombinant SARS-CoV-2 RBD adjuvanted …

Intranasal administration of RBD nanoparticles confers induction of mucosal and systemic immunity against SARS-CoV-2

T Jearanaiwitayakul, M Seesen, R Chawengkirttikul… - Vaccines, 2021 - mdpi.com
… Our findings imply that intranasal administration of RBD immunogens directed … intranasal
administration may not only prevent mucosal infection but also limit subsequent SARS-CoV-2 …

Oral and intranasal vaccines against SARSCoV‐2: Current progress, prospects, advantages, and challenges

S Kar, P Devnath, TB Emran, TE Tallei… - Immunity …, 2022 - Wiley Online Library
… doses, with both IM and intranasal routes. Su et al. used … intranasal booster vaccines. Both
groups showed efficient immune responses against SARS-CoV-2 infection, and the intranasal

[HTML][HTML] An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

AO Hassan, S Shrihari, MJ Gorman, B Ying, D Yuan… - Cell reports, 2021 - cell.com
… an intranasally administered spike protein-based chimpanzee adenovirus-vectored vaccine
(ChAd-SARS-CoV-2-… A single intranasal dose of ChAd-SARS-CoV-2-S induced durably high …

An intranasal ASO therapeutic targeting SARS-CoV-2

C Zhu, JY Lee, JZ Woo, L Xu, X Nguyenla… - Nature …, 2022 - nature.com
… Here we show that intranasally administered LNA ASOs represent a promising therapeutic
strategy for virus-induced respiratory diseases such as COVID-19. Importantly, our study …

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge

RG King, A Silva-Sanchez, JN Peel, D Botta… - Vaccines, 2021 - mdpi.com
… in VAED following SARS-CoV-2 infection. Our data showed that intranasal administration of
… These data therefore indicated that intranasal administration of AdCOVID did not potentiate …

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

PC Proud, D Tsitoura, RJ Watson, BY Chua… - …, 2021 - thelancet.com
… that prophylactic intra-nasal administration of the TLR2/6 agonist INNA-051 in a SARS-CoV-2 …
After 5 days post-exposure to SARS-CoV-2, INNA-051 significantly reduced virus in throat …

A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tracts

MD Schultz, JJ Suschak, D Botta… - Human Vaccines & …, 2022 - Taylor & Francis
… We report that a single intranasal administration of AdCOVID significantly decreased the
copies of viral RNA in SARS-CoV-2 challenged mice compared to vehicle controls. AdCOVID …

Prophylactic and therapeutic intranasal administration with an immunomodulator, Hiltonol®(Poly IC: LC), in a lethal SARS-CoV-infected BALB/c mouse model

Y Kumaki, AM Salazar, MK Wandersee, DL Barnard - Antiviral research, 2017 - Elsevier
… as SARS-CoV and MERS-CoV to which our populations have little or no immunity was
highlighted by SARS … , no agents have been approved for treating SARS-CoV or MERS-CoV. …