… In this article, the current approaches used to develop effective oral and nasal mucosal vaccines against SARS‐CoV‐2 and their benefits, prospects, and challenges have been …
… jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally administered spike protein-based chimpanzee adenovirus-vectored vaccine (ChAd-SARS-CoV-…
M Tiboni, L Casettari, L Illum - International journal of pharmaceutics, 2021 - Elsevier
… So far, all the approved vaccines are by intramuscular (IM) injection only, although different … on development of an intranasal (IN) SARS-CoV-2 vaccine. Ideally a vaccine, at least against …
HB Thapa, AM Müller, A Camilli, S Schild - Frontiers in Microbiology, 2021 - frontiersin.org
… vaccine-platforms, which are safe, effective, and can be modified to carry antigens of emerging pathogens. The current SARS-CoV-2 vaccines … a novel SARS-CoV-2 vaccine candidate …
MW Ku, M Bourgine, P Authié, J Lopez, K Nemirov… - Cell host & …, 2021 - cell.com
… vaccine efficacy and inhibit lung deleterious injury in golden hamsters, which are naturally permissive to SARS-CoV-… -based vaccination against SARS-CoV-2 and designate intranasal …
… 2 virus breaches before dissemination to the lung. We report the development of an intranasal subunit vaccine … This vaccine induces systemic neutralizing antibodies, IgA in the lung and …
N van Doremalen, JN Purushotham… - Science translational …, 2021 - science.org
… intranasally administered ChAdOx1 nCoV-19 reduces detection of virus in nasal swabs after challenging vaccinated macaques and hamsters with SARS-CoV-2 carrying a D614G …
… At 3 days after SARS-CoV-2 challenge, intranasallyvaccinated hamsters had lower viral loads in both the lung and nasal turbinates relative to mock vaccination, as determined by …
J Huang, Y Ding, J Yao, M Zhang, Y Zhang, Z Xie… - Vaccines, 2022 - mdpi.com
… The development of SARS-CoV-2 vaccines is diverse, and the development of nasal vaccines is mainly focused on viral vector vaccines and protein subunit vaccines. As a …