Jun, the oncoprotein

PK Vogt - Oncogene, 2001 - nature.com
Jun induced transormation and secondarily with transformation by oncoproteins that depend
on Jun, … receptor does not affect oncoproteins that are independent of Jun action, eg Myc (…

Jun: transcription factor and oncoprotein

HJ Rahmsdorf - Journal of molecular medicine, 1996 - Springer
… The following sections concentrate on the three mammalian jun genes, c-jun, … proteins in
relation to the oncoprotein v-jun. The RNAs are transcribed from intronless genes. The proteins

The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous

K Struhl - Cell, 1987 - cell.com
… and GCN4 Bind the Same DNA Sequences The main result of this work is that the C terminus
of the jun oncoprotein can functionally replace the GCN4 DNAbinding domain in vivo. The …

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

P Angel, EA Allegretto, ST Okino, K Hattori, WJ Boyle… - Nature, 1988 - nature.com
… indicate that the JUN oncoprotein is a sequencespecific transcriptional activator similar to …
-O-tetradecanoyl phorbol 13-acetate) function by activating protein kinase C (ref. 22), so it has …

The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast

K Struhl - Nature, 1988 - nature.com
… The JUN protein almost certainly represents the oncogenic version of the normal AP-1 …
between yeast and vertebrate activator proteins. Here, I demonstrate that JUN efficiently activates …

Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

M Hibi, A Lin, T Smeal, A Minden… - Genes & …, 1993 - genesdev.cshlp.org
The activity of c-Jun is regulated by phosphorylation. Various stimuli including transforming …
amino-terminal activation domain of c-Jun and thereby potentiate its trans-activation function. …

Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation

M Chiariello, MJ Marinissen… - Molecular and Cellular …, 2000 - Taylor & Francis
… In this regard, members of the AP-1 (activating protein 1) family of transcription factors
are frequently regulated at the transcriptional and posttranscriptional levels by MAPKs. AP-1 …

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73

T Smeal, B Binetruy, D Mercola… - … and Cellular Biology, 1992 - Taylor & Francis
… c-Jun activation domain. We show that these oncoproteins form part of a biochemical pathway
… transmits information from membrane-associated tyrosine kinases to c-Jun in the nucleus. …

The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells

R Alani, P Brown, B Binétruy, H Dosaka… - … and cellular biology, 1991 - Taylor & Francis
… -Jun proto-oncoprotein which are required for transformation and transcriptional activation in
RECs… Previous investigations of the structurefunction relationships of the c-Jun protein have …

Molecular targets of the oncogenic transcription factor jun

M Hartl, AG Bader, K Bister - Current Cancer Drug Targets, 2003 - ingentaconnect.com
… by the Jun oncoprotein, it is assumed that only the combined differential expression of Jun
… encodes a major component of the transcription factor complex activating protein-1 (AP-1) [8…