… Mice are commonly used to study … for SARS-CoV-2 infection because mouse ACE2 (mACE2)
is not an appropriate receptor for SARS-CoV-2 and does not facilitate the entry of the virus …

… In the current study, we evaluated K18-hACE2 transgenic mice in response to multiple …
response to SARS-CoV-2 infection. We also evaluated the response of K18-hACE2 mice to high-…

… In summary, we found that SARS-CoV-2 infection of K18-hACE2-transgenic mice supports
robust viral replication in the lung, which leads to severe immune cell infiltration, inflammation …

… Thus, our results with ORFΔ8 rSARS-CoV-2 in the K18 hACE2 transgenic mouse model …
natural ORFΔ8 SARS-CoV-2 isolate (20). Our findings with ORFΔ3a and ORFΔ6 rSARS-CoV-2s …

… As such, comorbid conditions (eg., obesity, hypertension, diabetes) that alter ACE2 … transgenic
mouse. In summary, we found that SARS-CoV-2 infection of K18-hACE2 transgenic mice …

… K18 ACE2 transgenic mice produced a modest TH1/2/17 cytokine storm in the lung and
spleen that peaked by day 2, and an extended chemokine storm that was detected in both lungs …

… The development of mouse models for coronavirus disease 2019 (COVID-19) … coronavirus
2 (SARS-CoV-2) pathogenesis. SARS-CoV-2 disease is severe in K18 transgenic mice (K18-…

… 161 on SARS-CoV-2 infection in k18-hACE2 transgenic (SARS-CoV-2 susceptible) mice in
vivo… -161 in a human ACE2 receptor-expressing K18 mouse model of SARS-CoV-2 infection. …

… To further explore the mechanism driving lethal SARS-CoV-2 infection in K18-hACE2 mice,
we investigated the tissue and cellular distribution of the ACE2 receptor and hACE2 mRNA …

… in the brain of K18-hACE2 transgenic mice compared to ACE2 expression in the human
brain [49]. This finding underlines the usefulness of K18-hACE2 transgenic mice to study CNS-…