… Our results support neuroinvasion as the primary cause of mortality in the K18-hACE2 mouse
model. This claim was supported by the observation that viral load and titers peaked in the …

… Our results support neuroinvasion and subsequent near global neurodissemination within
the brain as the primary cause of mortality in the K18-hACE2 mouse model irrespective of …

… -2-induced lethal disease in K18-hACE2 mice. Intranasal inoculation of the virus results in
a lethal … Some animal coronaviruses, such as MHV readily infect neurons and cause lethal …

… While a study of the brain of fatal human COVID-19 cases … [26], neuroinvasion and spread
in the K18-hACE2 mice is … ACE2 expression in the K18-hACE2 mice represents only the …

… dose we examined groups of K18-hACE2 mice that had been … While a study in the brain
of fatal human COVID-19 cases … [26], neuroinvasion and spread in the K18-hACE2 mice is …

… Overall, the data indicate that IN, but not AR, infection of K18-hACE2 transgenic mice
with SARS-CoV-2 results in lethal neuroinvasion likely via retrograde axonal transport after …

… leading to fatal neuroinvasion. However, pathology and inflammation of the lungs in
aerosol-infected mice lead to more severe consequences compared with intranasal inoculation. …

… While a study of the brain of fatal human COVID-19 cases … [26], neuroinvasion and
spread in the K18-hACE2 mice is … ACE2 expression in the K18-hACE2 mice represents only …

… In addition, histopathological analysis revealed that B1.617.2 infects the brain of K18-hACE2 …
neuroinvasive properties of SARS-CoV-2 variants in K18-hACE2 mice and link them to fatal …

… Here, in the susceptible transgenic K18-hACE2 mouse … bulb infection as the principal route
of neuroinvasion 4,6,15 . To … 63, they were challenged with a lethal intranasal dose of SARS-…