… In the lungs of aged hACE2 mice, SARS-CoV-2 infection leads to elevated cytokine … Here,
we show that SARS-CoV-2 infection of K18-hACE2 mice elicits a measurable systemic and …

… nonhuman primates (25), our results suggest that SARS-CoV infection of K18-hACE2
mice began in airway epithelial cells. Viral antigen is detected primarily in pneumocytes and …

… We report that using our RG-SARS-CoV-2 infectious clones, infection of hACE2-K18 mice
reproduces the clinical signs and pathology associated with severe COVID-19, validating the …

… In fact, while hACE2 expression is mainly limited to lung epithelia in K18-hACE2 mice, the
… intestine, testes, and lung in humans. Therefore, the presence of high levels of hACE in the …

… hACE2 mouse models, which also detected signs of lung injury including interstitial pneumonia,
inflammatory cell infiltrates, and alveolar septal thickening. Consistent with the observed …

… of K18-hACE2 mice infected … K18-hACE2 mouse model of severe COVID-19, provides
essential observation and analysis on the pathogenicity and immune response of Delta infection. …

… of infected K18-hACE2 mice by performing bulk RNA sequencing (RNA-seq) of lung
homogenates 6 days after SARS-CoV-2 infection. … between AR-infected, IN-infected, and …

… Together, these results indicate that lung disease in K18-hACE2 mice shares features with
severe COVID-19. Another characteristic of severe human COVID-19 is an early antibody …

… -2 ORF3a and ORF6 contribute to lung pathology and ultimately disease outcome in K18 …
Thus, our results with ORFΔ8 rSARS-CoV-2 in the K18 hACE2 transgenic mouse model …

… , we infected K18-hACE2 mice and … Lung histopathological images showed that all K18-hACE2
mice and hamsters exhibited progressive pulmonary disease after SARS-CoV-2 infection …