Cytokine storm syndrome (CSS) has generally been … Cytokine storms (CSs) are associated
with various pathologies, … cytokine release and cell death pathways; certain cytokines, …

… support the concept that “cytokine storm” is too broad a term to be used for the many types
of hypercytokinemia, which was recently corroborated by a comparison of IL-1β, IL-6, IL-8 and …

… impaired capacity to produce interferons, key mediators for a properly host response against
… It is known that the local RAAS can mediate pro-inflammatory, prothrombotic, and profibrotic …

… as direct mediators of the CRS of COVID-19, hence this article will focus on new frontiers
in targeting … IL-6 and TNF- α are key mediators of the cytokine release syndrome in COVID-19 …

… A hyperinflammatory state referred to as cytokine storm in its severest form has been marked
by elevation of IL-6, IL-10, TNF-α, and other cytokines and severe CD4 + and CD8 + T-cell …

… using pro-resolution mediators as a potential … mediators promote clearance of cellular debris
and activate anti-inflammatory programs to inhibit several key pro-inflammatory cytokines [9, …

… Interleukin-6, a proinflammatory cytokine, is a key mediator in the acute inflammatory response
and the purported cytokine storm. The Table summarizes reported IL-6 levels in 5 cohorts …

… cytokine storm has become a key therapeutic target. Although specific mechanisms of the
occurrences of cytokine storms … exposed to circulating cytokines and other immune mediators, …

… Although multiple cytokines are reportedly associated with disease severity, the key
mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully …

… Some 40 key background papers that demonstrate the … made possible by rTNF, the key
predictions of the model stood the … to have opted out of cytokines as mediators in malaria, instead …