Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer characterized by
inactivation of the von Hippel-Lindau (VHL) gene in ∼90% of patients. VHL is the substrate …

… transcriptional level. Many of the gene mutations associated with kidney malformations and
disease are indeed transcription … significant transcription factors in mouse nephrogenesis. …

… PBRM1, a subunit of the PBAF coactivator complex that transcription factors use to … cell
cancers (RCCs). Using unbiased proteomic analyses, we find that PAX8, a master transcription …

… in activation of AR-driven pathways and cancer progression. Owing to the context-… kidney
cancers is needed to improve our understanding of its role in the development of these cancer …

… and transcription factors linked to those enhancers in breast, prostate, and kidney cancers,
will … To understand the mechanisms underlying breast, prostate, and kidney cancers, we …

… samples, we demonstrate that the lineage transcription factor paired box 8 (PAX8) …
transcriptional enhancers, including a pro-tumorigenic cyclin D1 (CCND1) enhancer that is …

… Thus, gene clusters solely identified from analyses of normal kidney transcriptomes appeared
to be under similar transcriptional control in tumors as was observed in normal renal cells. …

… High levels of hypoxia-inducible transcription factors (HIF) are particularly important in the
clear cell type of kidney cancer, in which they are no longer properly regulated by the von …

Hypoxic stress and hypoxia-inducible factors (HIFs) play important roles in a wide range of
tumors. We demonstrate that SPOP, which encodes an E3 ubiquitin ligase component, is a …

… We demonstrate that kidney cancer is characterized by increased amounts of methylation
that affects introns. These areas of increased methylation preferentially affect regulatory …